silica dust, crystalline, in the form of quartz or cristobalite - IARC ...

IARC MONOGRAPHS – 100C
Table 3.4 Incidence, numbers, and histological types of lung tumours in female Wistar rats after intratracheal instillation of
quartz
Material Surface
area
No. of
instillations
No. of rats
examined
No. and #% of rats with primary epithelial lung tumours a Other
tumours b
(m 2 /g) (del # × mg) Adenoma Adenocarcinoma Benign
CKSCT
Squamous
cell
carcinoma
Quartz (DQ 12) 9.4 15 × 3 37 0 1z 11 1 + 1y 38 1
Quartz (DQ 12) + PVNO 9.4 15 × 3 38 0 1 + 3z 8 + 1x 4+1x+3y+1z 58 2
Quartz (DQ 12) 9.4 1 × 45 40 0 1 7 1 23 2
Quartz (Min-U-Sil) – 15 × 3 39 1 4 + 4z 6 1+2y+2z+1y,z 54 3
Quartz (Min-U-Sil) + PVNO – 15 × 3 35 1 2 + 1x 8 5+1x+1y+1z 57 3
Quartz Sykron (F 600) 3.7 15 × 3 40 0 3 5 3 + 1z 30 1
0.9% Sodium chloride – 15 × 0.4 mL 39 0 0 0 0 0 5
Total
(%)
a
If an animal was found to bear more than one primary epithelial lung tumour type, this was indicated as follows: x adenoma; y adenocarcinoma; z benign CKSCT.
b
Other types of tumours in the lung: fibrosarcoma, lymphosarcoma, mesothelioma or lung metastases from tumours at other sites
PVNO, polyvinylpyridine-N-oxide; CKSCT, cystic keratinizing squamous cell tumour
From Pott et al. (1994)
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