CHOLERA- Dr. J.J. Kambona [Compatibility Mode]

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Virulence factors for vibrio cholerae 01 3. Vibrio cholerae adhere to the intestinal wall by the fimbria, filamentous protein structures called toxin-coregulated pilus (TCP), extending from the cell wall and that attach vibrio cholerae to the receptors on the mucosa. 4. Bacterium’s motility helps to penetrate the mucus overlying the mucosa. With high concentration of vibrio cholerae closely attached to the mucosa, enterotoxin can be efficiently delivered directly to the mucosal cells.
Pathogenesis Once established, the organisms produce cholera toxin that consists of subunits A and B. The B-subunit is physiologically inactive but binds the toxin to the receptors in the small intestinal mucosa. Then, A-subunit is the transported into the cell where it transfers Adenosine Diphosphate (ADP) into Cyclic Adenosine Monophosphate (cAMP) and activate it.
Page 2 and 3: CHOLERA Presenter: Dr. J.J. Kambona
Page 4 and 5: Background The term ‘cholera’
Page 6 and 7: Epidemiology A. Geographical: Chol
Page 8 and 9: Host susceptibility factors 3. Bloo
Page 10 and 11: Transmission Transmission is norma
Page 12 and 13: Cholera pandemics in the world 1. F
Page 14 and 15: Cholera Epidemics in Tanzania 4. 2
Page 16 and 17: Cause Vibrio cholerae 01 and vibri
Page 18 and 19: Classification Biotypes: The 01 ser
Page 20 and 21: Virulence factors for vibrio choler
Page 24 and 25: Pathogenesis The activated Cyclic
Page 26 and 27: History Incubation period is betwe
Page 28 and 29: Assessment of the patient with diar
Page 30 and 31: Dehydration Patients with severe d
Page 32 and 33: Differential diagnoses A. Malaria.
Page 34 and 35: Complications 8. Complications of t
Page 36 and 37: Vibrio cholerae
Page 38 and 39: Investigations 4. Stool culture: Ro
Page 40 and 41: Investigations 6. Renal functional
Page 42 and 43: I. Severe dehydration A. Administer
Page 44 and 45: I. Severe dehydration C. Reassess a
Page 46 and 47: II. Some dehydration Reassess the
Page 48 and 49: III. No dehydration Instruct the p
Page 50 and 51: Antibiotics Azithromycin 1 g
Page 52 and 53: Prevention 1. Early identification
Page 54 and 55: Prevention 7. Vaccines: A. WC/rBS v
Page 56 and 57: Prognosis With effective intrave
Page 58: References 1. Thaker V.V. Cholera.

CHOLERA- Dr. J.J. Kambona [Compatibility Mode]

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