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National Nutrition and HIV/AIDS Guidelines for Service Providers of ...

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Medication<br />

Purpose<br />

Recommendation/ advice<br />

Potential side effects<br />

Indinavir (IDV)<br />

Antiretroviral<br />

1 hour be<strong>for</strong>e or 2 hours after meal.<br />

Drink at least 1,500ml <strong>of</strong> fluid daily.<br />

Do not drink grapefruit juice as it<br />

may lower the level <strong>of</strong> medicine in<br />

the blood.<br />

Avoid St. John's wort.<br />

Nausea, abdominal pain,<br />

headache, kidney stones, taste<br />

changes, vomiting, regurgitation,<br />

diarrhea, insomnia, ascites,<br />

weakness, <strong>and</strong> dizziness. May<br />

increase the risk <strong>of</strong> lipodystrophy.<br />

Lamivudine<br />

(3TC)<br />

Antiretroviral<br />

Can be taken without regard to food.<br />

Avoid alcohol.<br />

Nausea, vomiting, headache,<br />

dizziness, diarrhea, abdominal<br />

pain, nasal symptoms, cough,<br />

fatigue, pancreatitis, anaemia,<br />

insomnia, muscle pain, <strong>and</strong> rash<br />

Lopinavir<br />

Antiretroviral<br />

Can be taken without regard to food.<br />

Avoid St John's<br />

Abdominal pain, diarrhea,<br />

headaches, headache, weakness,<br />

nausea. May increase the risk <strong>of</strong><br />

lipodystrophy <strong>and</strong> or diabetes.<br />

Nelfinavir<br />

Antiretroviral<br />

With meal or light snack. Do not take<br />

with citrus juices or apple sauce.<br />

Avoid St John's wort.<br />

Diarrhea, flatulence, nausea,<br />

abdominal pain, <strong>and</strong> rash. May<br />

increase the risk <strong>of</strong><br />

lipodystrophy.<br />

Nevirapine (NVP)<br />

Antiretroviral<br />

Can be taken without regard to food.<br />

Avoid St John's wort.<br />

Nausea, vomiting, rash, fever,<br />

headache, skin reactions,<br />

fatigue, stomatitis, abdominal<br />

pain, drowsiness, paresthesia.<br />

High hepatotoxicity.<br />

Ritonavir<br />

Antiretroviral<br />

With meals if possible. Avoid St<br />

John's wort.<br />

Nausea, vomiting, diarrhea,<br />

hepatitis, jaundice, weakness,<br />

anorexia, abdominal pain, fever,<br />

diabetes, headache, dizziness.<br />

May increase the risk <strong>of</strong><br />

lipodystrophy<br />

Saquinavir<br />

Antiretroviral<br />

With a meal or a light snack; take<br />

within 2 hours <strong>of</strong> a fat containing<br />

meal <strong>and</strong> high calcium meal. Do<br />

not take with grape juice due to<br />

acidity.<br />

Avoid garlic supplements <strong>and</strong> St<br />

John's wort.<br />

Mouth ulceration, taste changes,<br />

nausea, vomiting, abdominal<br />

pain, diarrhea, constipation,<br />

flatulence, weakness rash, <strong>and</strong><br />

headache. May increase the risk<br />

<strong>of</strong> lipodystrophy.<br />

Stavudine (d4t)<br />

Stavudine (d4t)<br />

Can be taken without regard to<br />

food.<br />

Must be stored in a refrigerator.<br />

Nausea, vomiting, diarrhoea,<br />

peripheral neuropathy, chills <strong>and</strong><br />

fever, anorexia, stomatitis,<br />

diarrhoea, anaemia, headaches,<br />

rash, bone marrow, <strong>and</strong><br />

pancreatitis.<br />

May increase the risk<br />

lipodystrophy. Limit the<br />

consumption <strong>of</strong> alcohol.<br />

Ten<strong>of</strong>ovir (TDF)<br />

Antiretroviral<br />

With food<br />

Abdominal pain, headache,<br />

fatigue, <strong>and</strong> dizzinessAbdominal<br />

pain, headache, fatigue, <strong>and</strong><br />

dizziness<br />

42

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