Overview of bioengineering and hydrocephalus: 50 years in 30 ...

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Proximal obstruction: testing • Pat McAllister, Carolyn Harris • Flow‐based cell culture system for testing proximal catheter obstruction (& valves too) “Mechanical contribution to astrocyte adhesion using a novel in vitro model of catheter obstruction.” Harris, Resau, Hudson, West, Moon, McAllister. Exptl Neurology (2010).
Obstruction: status and needs • Proximal catheter obstruction (60%) • Coatings: no proven solutions yet, but promising • Active methods: intriguing but research stage • Better CSF control may reduce failure (OSV) • Valve obstruction (30%) • Possible issues with ih valve designs: complex flow path, small gaps, CSF contacts intricate parts • Little‐to‐no activity to reduce valve obstruction • Need in vitro biological models to evaluate new obstruction‐prevention bt ti ti methods
Page 1 and 2: Barry Lutz, Ph.D. Research Assistan
Page 3 and 4: Shunt history: 50 years in 5 minute
Page 5 and 6: Shunt history: 50 years in 5 minute
Page 7 and 8: What can we do to really advance th
Page 9 and 10: Proximal obstruction: geometry •
Page 11 and 12: Proximal obstruction: coatings Prom
Page 13: Proximal obstruction: active method
Page 17 and 18: Reader‐based flow diagnostics •
Page 19 and 20: Reader‐based flow diagnostics •
Page 21 and 22: Pressure Sensor Requirements AMF mi
Page 23 and 24: Diagnostics: status of systems •
Page 25 and 26: Smart Shunts: Codman & Shurtleff
Page 27 and 28: Smart Shunts: Integra Lifesciences
Page 29 and 30: Smart Shunts: tube squeezer • Tub
Page 31 and 32: Advanced models of CSF dynamics •
Page 33 and 34: Summary: potential wins in next 5 y
Page 36 and 37: Needs with promise in next 3‐5 ye

Overview of bioengineering and hydrocephalus: 50 years in 30 ...

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