IAH AC Gastrointestinal Disease

Vicious cycles of changed permeability
• Immune activation or suppression
• Food intolerance
• Hepatic overload
• Bacterial dysbiosis
• Low grade pancreatitis (partially digested foods)
© IAH 2007
15
Increased permeability will led to a couple of vicious cycles:
The first is an increase in food intolerance and also changes in the immunity.
The immunity goes down when the symbiotic bacteria are not stimulating the
immune system enough, whereas if the food and toxic particles get into the gut
lining in too high quantities,it will set off an inflammatory process. (see the next
slides)
The liver, being the last barrier, will bear the brunt of chemicals and
environmental toxins leaking through the gut lining, and all patients with a leaky
gut should be considered to have liver overload.
The symbiotic bacteria and the gut lining have a very special relationship.
The gut lining, if healthy, will maintain a milieu for the bacteria, and conversely,
the bacteria will in their metabolism secrete substances such as propionic acid,
which will act as a fuel source for the gut cells. New evidence even suggest this
symbiotic relationship to exist to the point where there is cell to cell
communication between the bacteria and the gut lining. If the permeability is
disturbed this is lost, and dysbiosis will ensue.
Lastly we see a low grade malapsorbtion, as the exocrine pancreas is affected.
15