amine 1.1 Primary amine , 1o amine , RNH 1.2 Secondary amine ...
amine 1.1 Primary amine , 1o amine , RNH 1.2 Secondary amine ...
amine 1.1 Primary amine , 1o amine , RNH 1.2 Secondary amine ...
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¡ÒÃ<br />
ÒÃàµ<br />
àµÃÕÂ<br />
ÃÕÂÁ Amines<br />
3. . Reductive amination<br />
Ex<br />
H<br />
CH3C=O + NH2<br />
C=O + NH3<br />
+ <strong>RNH</strong>2<br />
+ R2NH<br />
O<br />
H2/Ni<br />
CH3CCH3 + NH3<br />
H2/Ni or<br />
NaBH3CN CH-NH 2<br />
CH-NHR<br />
CHNR2<br />
NaBH3CN<br />
NH2<br />
CH3-CH-CH3<br />
H<br />
NCH2CH(CH3)2<br />
¡ÒÃ<br />
ÒÃàµ<br />
àµÃÕÂ<br />
ÃÕÂÁ Amines<br />
4. . Reduction of nitrile<br />
H2/Ni<br />
R-C N R-CH2NH2<br />
Ex<br />
NaCN<br />
H2/Ni<br />
ClCH2CH2CH2Cl CN(CH2)3CN H2NCH2(CH2)4CH2NH2<br />
CH2Cl CH2CN CH2CH2NH2<br />
NaCN<br />
H2/Ni<br />
¡ÒÃ<br />
ÒÃàµ<br />
àµÃÕÂ<br />
ÃÕÂÁ Amines<br />
5. . Hofmann degradation of amide<br />
O O<br />
R-CNH2 or Ar-CNH2 KOBr R-NH2 or Ar-NH2 + CO3 2-<br />
Ex<br />
O<br />
CH3CH2CH2CNH2<br />
O<br />
CNH2<br />
Br<br />
KOBr<br />
KOBr<br />
NH2<br />
CH3CH2CH2NH2<br />
Br<br />
Home work II<br />
Amines ก<br />
<br />
1<br />
CH3<br />
CH2NH2<br />
?<br />
?<br />
2 CH2=CH2 NH2CH2CH2CH2CH2NH2
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