Luc De Vuyst.pdf - ICoMST Contact Point
Luc De Vuyst.pdf - ICoMST Contact Point
Luc De Vuyst.pdf - ICoMST Contact Point
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<strong>De</strong> <strong>Vuyst</strong>, Avonts & Makras (2004). Woodhead Publishing, Ltd., Cambridge, UK<br />
Important criteria for probiotics<br />
Probiotics: selection criteria<br />
- Human origin and non-pathogenic behaviour<br />
- Survive passage through the upper gastrointestinal tract<br />
- resistance to gastric acid and bile toxicity, digestive enzymes, …<br />
- active during transit from stomach to colon (expression of genes during intestinal<br />
transit)<br />
- Interact with the resident microbiota<br />
- ability to transiently adhere to or interact with the intestinal epithelium and colonize the<br />
colon<br />
- do not affect the dominant microbiota significantly<br />
- have an effect on the numbers and diversity of the endogenous Lactobacillus and<br />
Bifidobacterium species<br />
- Affect the function of the host:<br />
- probiotic-host interactions (functional genomics, clinical trials and human intervention<br />
studies)<br />
- prevention of (the risk on) disease (meta-analyses)<br />
- Resistant towards technological processing and storage<br />
- importance of the food matrix and the applied process technology<br />
- stable/alive till the moment of consumption (the number of live, active cells is<br />
important)<br />
- High safety profile and excellent tolerance (Lb. rhamnosus, D-lactic acid)
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