Luc De Vuyst.pdf - ICoMST Contact Point
Luc De Vuyst.pdf - ICoMST Contact Point
Luc De Vuyst.pdf - ICoMST Contact Point
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Probiotics: mechanism of action<br />
1. Probiotics influence microbe-microbe interactions<br />
- Competition for nutrients available in the gut lumen<br />
- Production of antimicrobial or toxic agents modifying the local<br />
microenvironment and hence contributing to survival<br />
2. Probiotics influence microbe-gut epithelium interactions<br />
- Competitive exclusion along the epithelium<br />
- Enhancement of the epithelial barrier function<br />
- Suppression of intestinal inflammation<br />
3. Probiotics influence microbe-immune system interactions and<br />
modulate the host immune response<br />
- Cell-mediated immune responses<br />
- Humoral (antibody-mediated) and innate immune responses<br />
(<strong>De</strong> <strong>Vuyst</strong>, Avonts & Makras (2004). Woodhead Publishing, Ltd.; Servin & Coconnier (2004). Best Pract. Res.<br />
Gastroenterol.; Servin (2004). FEMS Microbiol. Rev.; Rastall et al. (2005). FEMS Microbiol. Ecol.;<br />
Saxelin et al. (2005). Curr. Opinion Biotechnol.; O’Hara & Shanahan (2007). Scientific World Journal;<br />
Galdeano et al. (2007). Clin. Vaccine Immunol.)
Change language