Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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Methods to estimate GFR • Cockcroft-Gault (CG) equation 7 • Modified CG equation • MDRD equation 8 • CKD-EPI equation 9 • 24-Hour endogenous creatinine clearance 1,10 1. Macdiarmid SA. BJU International, 2000; 85: 1014-18. 7. Cockcroft DW. Nephron 1976; 16: 31–41. 8. Stevens LA. J Am Soc Nephrol, 2007; 18: 2749-57. 9. Levey AS. Ann Intern Med, 2009; 150(9): 604-12. 10. Stabuc B. Clinical Chemistry, 2000; 46(2): 193-7.
Cockcroft-Gault (CG) 7 CL CG (mL/min) = [(140 – age) x IBW in kg] / (72 x SCr); (multiply 0.85 for females) Modified CG formula (CL M ): • SCr rounded to 1 mg/dL for patients with SCr < 1 mg/dL while using the actual SCr for patients with SCr ≥ 1 mg/dL 7. Cockcroft DW. Nephron 1976; 16: 31–41.
Page 1 and 2: Evaluation of Methods to Estimate R
Page 3 and 4: Disclosures • Jennifer Lee, Pharm
Page 5 and 6: VA Long Beach Healthcare System •
Page 7 and 8: Creatinine • A muscle breakdown p
Page 9: Vancomycin & Aminoglycosides • Do
Page 13 and 14: MDRD equation 8 4-Variable MDRD: eG
Page 15 and 16: CKD-EPI equation 9 eGFR = 141 x min
Page 17 and 18: 24-Hour Endogenous Creatinine Clear
Page 19 and 20: Inclusion Criteria • Patients at
Page 21 and 22: Methodology • VA electronic medic
Page 23 and 24: Methodology • Actual drug clearan
Page 25 and 26: Results
Page 27 and 28: Evaluation of different methods to
Page 29 and 30: Number of Patients Difference betwe
Page 31 and 32: Actual Drug Clearance (mL/min) 120
Page 33 and 34: CL DRUG vs. CL SCI • T-Test showe
Page 35 and 36: DISCUSSION
Page 37 and 38: Discussion • CL SCI = 2.3286 * x
Page 39 and 40: Conclusion • Current methods used
Page 41 and 42: References 1. Macdiarmid S, Mcintyr
Page 43: Post-Test Assessment Questions •

Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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