Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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Limitations • Small number of patients in amikacin group • Veterans population • Variability inherent in using clinical data • Assumption: CL CR =CL V =CL AG • Accuracy of vancomycin Vd • Actual GFR values for > 60 ml/min • Abbreviated MDRD • No adjustment for BSA • Retrospective study: limited control over certain confounding variables
Conclusion • Current methods used to calculate CL CR overestimate CL DRUG in SCI patients • The proposed SCI equation: CL SCI = 2.3*x 0.7 (x = CL M with SCr rounded to1 if SCr
Page 1 and 2: Evaluation of Methods to Estimate R
Page 3 and 4: Disclosures • Jennifer Lee, Pharm
Page 5 and 6: VA Long Beach Healthcare System •
Page 7 and 8: Creatinine • A muscle breakdown p
Page 9 and 10: Vancomycin & Aminoglycosides • Do
Page 11 and 12: Cockcroft-Gault (CG) 7 CL CG (mL/mi
Page 13 and 14: MDRD equation 8 4-Variable MDRD: eG
Page 15 and 16: CKD-EPI equation 9 eGFR = 141 x min
Page 17 and 18: 24-Hour Endogenous Creatinine Clear
Page 19 and 20: Inclusion Criteria • Patients at
Page 21 and 22: Methodology • VA electronic medic
Page 23 and 24: Methodology • Actual drug clearan
Page 25 and 26: Results
Page 27 and 28: Evaluation of different methods to
Page 29 and 30: Number of Patients Difference betwe
Page 31 and 32: Actual Drug Clearance (mL/min) 120
Page 33 and 34: CL DRUG vs. CL SCI • T-Test showe
Page 35 and 36: DISCUSSION
Page 37: Discussion • CL SCI = 2.3286 * x
Page 41 and 42: References 1. Macdiarmid S, Mcintyr
Page 43: Post-Test Assessment Questions •

Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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