Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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Future Plans • Validate CL SCI in a prospective analysis • Further analysis with aminoglycosides
References 1. Macdiarmid S, Mcintyre W, Anthony A, et. Al. “Monitoring of Renal Function in Patients with Spinal Cord Injury” BJU International 2000;85. 1014-1018 2. Mirahmadi MK, Byrne C, Barton C, et. Al. “Prediction of creatinine clearance from serum creatinine in spinal cord injury patients.” Paraplegia. 1983 Feb;21(1):23-9 3. Cherry R, Eachempati S, Hydo L et al. “Accuracy of Short-Duration Creatinine Clearance Determinations in Predicting 24-Hour Creatinine Clearance in Critically Ill and Injured Patients” J Trauma 2002; 53:267-271. 4. Rybak M, Lomaestro B, Rotschafer J et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health-Syst Pharm 2009; 66: 82-98. 5. Hidayat L, Hsu D, Quist R et al. High-Dose Vancomycin Therapy for Methicillin-Resist Staphylococcus aureus Infections: Efficacy and Toxicity. Arch Intern Med 2006; 166: 2138- 2144. 6. Kahlmeter G, Dahlager JI. Aminoglycoside Toxicity - A review of clinical studies published between 1975 and 1982. J Antimicrobial Chemotherapy 1984; 13: 9-22. 7. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31–41. 8. Stevens LA, Coresh J, Feldman HI, et al. Evaluation of the Modification of Diet in Renal Disease Study Equation in a Large Diverse Population. J Am Soc Nephrol, 2007; 18: 2749-57. 9. Levey AS, Stevens LA, Schmid CH, et al. A New Equation to Estimate Glomerular Filtration Rate. Ann of Intern Med, 2009; 150(9): 604-12.
Page 1 and 2: Evaluation of Methods to Estimate R
Page 3 and 4: Disclosures • Jennifer Lee, Pharm
Page 5 and 6: VA Long Beach Healthcare System •
Page 7 and 8: Creatinine • A muscle breakdown p
Page 9 and 10: Vancomycin & Aminoglycosides • Do
Page 11 and 12: Cockcroft-Gault (CG) 7 CL CG (mL/mi
Page 13 and 14: MDRD equation 8 4-Variable MDRD: eG
Page 15 and 16: CKD-EPI equation 9 eGFR = 141 x min
Page 17 and 18: 24-Hour Endogenous Creatinine Clear
Page 19 and 20: Inclusion Criteria • Patients at
Page 21 and 22: Methodology • VA electronic medic
Page 23 and 24: Methodology • Actual drug clearan
Page 25 and 26: Results
Page 27 and 28: Evaluation of different methods to
Page 29 and 30: Number of Patients Difference betwe
Page 31 and 32: Actual Drug Clearance (mL/min) 120
Page 33 and 34: CL DRUG vs. CL SCI • T-Test showe
Page 35 and 36: DISCUSSION
Page 37 and 38: Discussion • CL SCI = 2.3286 * x
Page 39: Conclusion • Current methods used
Page 43: Post-Test Assessment Questions •

Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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