Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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Evaluation <strong>of</strong> CL M to estimate CL DRUG for vancomycin and AG Mean ± S.D. (mL/min) Difference from CL DRUG (mL/min) P-Value Combined Amikacin and Vancomycin (N=141) Amikacin (n=32) Vancomycin (n=109) CL DRUG 49.77 ± 19.97 0 -- CL M 69.38 ± 13.49 19.61
Actual Drug Clearance (mL/min) 120 Determining SCI Study Equation 100 80 60 40 y = 2.3286x 0.7 R = 0.4 20 0 0 20 40 60 80 100 120 Modified Cockcr<strong>of</strong>t-Gault Predicted Drug Clearance (mL/min)
Page 1 and 2: Evaluation of Methods to Estimate R
Page 3 and 4: Disclosures • Jennifer Lee, Pharm
Page 5 and 6: VA Long Beach Healthcare System •
Page 7 and 8: Creatinine • A muscle breakdown p
Page 9 and 10: Vancomycin & Aminoglycosides • Do
Page 11 and 12: Cockcroft-Gault (CG) 7 CL CG (mL/mi
Page 13 and 14: MDRD equation 8 4-Variable MDRD: eG
Page 15 and 16: CKD-EPI equation 9 eGFR = 141 x min
Page 17 and 18: 24-Hour Endogenous Creatinine Clear
Page 19 and 20: Inclusion Criteria • Patients at
Page 21 and 22: Methodology • VA electronic medic
Page 23 and 24: Methodology • Actual drug clearan
Page 25 and 26: Results
Page 27 and 28: Evaluation of different methods to
Page 29: Number of Patients Difference betwe
Page 33 and 34: CL DRUG vs. CL SCI • T-Test showe
Page 35 and 36: DISCUSSION
Page 37 and 38: Discussion • CL SCI = 2.3286 * x
Page 39 and 40: Conclusion • Current methods used
Page 41 and 42: References 1. Macdiarmid S, Mcintyr
Page 43: Post-Test Assessment Questions •

Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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