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UNIVERSITÀ DEGLI STUDI DI TRIESTE - OpenstarTs - Università ...

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Chapter 4 – State of the art of methods and instruments for analysis of respiratory parameters<br />

Chapter 4<br />

State of the art of methods and instruments<br />

for analysis of respiratory parameters<br />

Post-operative analysis of respiratory mechanics in mechanically ventilated patients is<br />

useful for evaluating patient status and assessing the effect of therapy in intensive care units<br />

(ICUs). It is important to have knowledge of two main quantities which characterize breathing<br />

mechanical properties; total compliance, often measured under static conditions as an<br />

indicator of lung and chest-wall elasticity and total flow resistance, which reflects properties<br />

of both the tissue and the peripheral airways.<br />

Several studies characterizing the main aspects of breathing mechanics have been<br />

published in recent years. These have used different lumped-parameter models, ranging from<br />

the simple two-element resistance-compliance linear model to more sophisticated<br />

physiological models which include tissue viscoelasticity, the inertial effects of the airways<br />

and branching networks, to non-linear models. However, working with non-linear models<br />

precludes the use of many powerful concepts usually adopted in the clinical investigation of<br />

respiratory mechanics (for example, the use of frequency-domain analysis: Bode diagrams<br />

and input impedance).<br />

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