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Chapter 6 – High Frequency Percussive Ventilator characterization Fig.6.8 VDR-4 : Measured flow (left panel) and pressure (right panel, black line) together with the estimated pressure (right panel, red line). The latter presents a more irregular profile than the measured pressure, especially in the bottom graph. E=20 cm H 2 O/l in all graphs; R=5,20,50 cm H 2 O/(l/sec) from top to bottom; frequency = 450 c/min. Even if our results are probably affected by the intrinsic limit of the lung model, as frequency dependence and a non-linear behaviour at the highest resistance, the possibility to have a real time respiratory parameters monitoring is useful for the clinical point of view. Is very important to emphasize that lung elastance is the main factor to avoid volutrauma during a pressure-controlled ventilation logic as pointed out in our recent study in which the elastance represents the most important cause of volume distribution in a two compartment model ventilated in HFPV [Lucangelo U et al 2010], while resistance does not play a particular role. For this reason the accurate estimation of elastance obtained by the computerized system is very important to set correctly the ventilator. In the present investigation our mathematical model constantly overestimates the elastance, avoiding the hazard of hyperinflation during HFPV. On the other hand, the compensative mathematical model resistance underestimation do not interfere with the delivered volume. 88
Chapter 6 – High Frequency Percussive Ventilator characterization Our instrument allows to satisfactorily estimate respiratory parameters in the range of values of clinical interest, both in the case of conventional ventilation and in the case of percussive ventilation. Current investigation is propaedeutic to further human studies. In this case it will be mandatory to assess the effect of inertance and implement more sophisticated algorithms. 89
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Index 2.2.7 Pressure-Controlled Ven
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Introduction Introduction The lungs
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Introduction The study was carried
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Physiology of the respiratory syste
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Chapter 2 - Intensive care: mechani
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Chapter 3 - The pulmonary function
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Page 97 and 98: Conclusions and future developments
Page 99 and 100: References References Annane D, Orl
Page 101 and 102: References Lucangelo U, Antonaglia
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UNIVERSITÀ DEGLI STUDI DI TRIESTE - OpenstarTs - Università ...

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