Master - FakultÃ¤t fÃ¼r Physik und Astronomie

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Ruprecht-Karls-University Heidelberg 38 Department of Physics and Astronomy Code: MVBP1 Course Title: Introduction to Biophysics Programme: <strong>Master</strong> of Science (Physics) Type: Lecture with exercises Credit Points: 6 Workload: 180 h Teaching Hours: 6/week Mode: WPM Term: WS Module Parts: • Lecture on “Introduction to Biophysics” (4 hours/week) • Exercise (2 hours/week) Module Contents: • Methods of structural biology (X-Rays, EM, NMR, LM) • Membranes and biological energy • Measurement of neural activity • Single Molecule Spectroscopy • Imaging of living tissue • Information in living tissue • Chemo-mechanical coupling • Catalysis Objective: Introduction to basic concepts of biophysics; practical exercises. Necessary/useful Knowledge: Content of PEP4, UKBio1, UKBio2 Recommended Literature: To be announced by lecturer Specialties: Exercises with homework Form of Testing and Examination: defined by lecturer before beginning of course 2012.1/v2
Ruprecht-Karls-University Heidelberg 39 Department of Physics and Astronomy Code: MVBP2 Programme: <strong>Master</strong> of Science (Physics) Course Title: Theoretical Biophysics Type: Lecture with exercises Credit Points: 6 Workload: 180 h Teaching Hours: 6/week Mode: WPM Term: SS Module Parts : • Lecture on “Theoretical Biophysics” (4 hours/week) • Exercise (2 hour/week) Module Contents: • Macromolecules -General properties of macromolecules: Freely jointed chain, the Gaussian chain model, elastic rod model, self avoiding chains, conformations and energy landscapes, macromolecules in solution, Macromolecules at a surface -Intermolecular interactions and electrostatic screening -Helix-Coil transition -DNA melting -Polyelectrolytes: The Poisson-Boltzmann equation -Proteins: Protein folding numerical approaches, folding as a spin glass problem Proteinprotein interactions -Chromatin: Chromatin models, force-extension behaviour of folded macromolecules -Genes: Gene expression and genetic code • Membranes - Self–assembly of micelles -Surface behaviour of lipids: differential geometry of surfaces, membrane elasticity and bending energy, membrane fluctuations -Structure of Lipids -Cell Membranes • Transport - Diffusion -Polymer dynamics: Rouse Model, hydrodynamic interactions • Networks - Gels -Metabolic Networks: Boolean networks, scale-free networks, robustness of networks • Molecular Motors -Polymerization of cell filaments -Brownian ratchet -A basic model of a molecular motor • Statistical Analysis -Bayesian Analysis -Monte Carlo Methods -Hidden Markov Models Objective: Introduction to theoretical concepts for physics of living matter Necessary/useful Knowledge: Basics of Classical Mechanics, Electrodynamics and Statistical Mechanics Recommended Literature: To be announced by lecturer Specialties: Exercises with homework Form of Testing and Examination: To be defined by lecturer before beginning of course 2012.1/v2
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Master - FakultÃ¤t fÃ¼r Physik und Astronomie

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