Electron Transport and Oxidative Phosphorylation
Electron Transport and Oxidative Phosphorylation
Electron Transport and Oxidative Phosphorylation
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Garrett <strong>and</strong> Grisham, Biochemistry, Third Edition<br />
Complex II Oxidizes Succinate<br />
<strong>and</strong> Reduces Coenzyme Q<br />
Succinate-CoQ Reductase<br />
• aka succinate dehydrogenase (from TCA cycle!)<br />
• aka flavoprotein 2 (FP 2 ) - FAD covalently bound<br />
• four subunits, including 2 Fe-S proteins<br />
• Three types of Fe-S cluster:<br />
4Fe-4S, 3Fe-4S, 2Fe-2S<br />
• Path: succinate → FADH 2 → 2Fe 2+ → UQH 2<br />
• Net reaction:<br />
succinate + UQ → fumarate + UQH 2