Statin/Ezetimbe Combination Therapy: Emerging Evidence

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Elevated Transaminases (% of Patients) % Decrease in LDL-C Risk:Benefit Ratio of StatinTitration Atorvastatin Lovastatin Simvastatin 0 10 mg 20 mg 40 mg 80 mg 20 mg 40 mg 80 mg 40 mg 80 mg -10 -20 -30 -40 -50 -60 2.5 2.0 1.5 1.0 0.5 0.0 10 mg 20 mg 40 mg 80 mg 20 mg 40 mg 80 mg 40 mg 80 mg Data from prescribing information for atorvastatin, lovastatin, simvastatin. This does not represent data from a comparative study.
Severe Adverse Event Rates for Each Trial: Meta-Analysis of Intensive vs Moderate Statin Therapy Cannon CP et al. JACC 2006;48:438–45
Page 1 and 2: Statin/Ezetimbe Combination Therapy
Page 3 and 4: Recommendations for Lipid Analyses
Page 5 and 6: Cholesterol Goal Attainment in Egyp
Page 7 and 8: Cholesterol Goal Attainment in Egyp
Page 9 and 10: Why do statins alone don’t get ou
Page 11: Statins Adverse Events • Hepatoto
Page 15 and 16: INHIBITION OF CHOLESTEROL SYNTHESIS
Page 17 and 18: Exogenous Endogenous Cholesterol Ab
Page 19 and 20: CAI THE INHIBITION OF CHOLESTEROL A
Page 21 and 22: Switching to Combination vs. Statin
Page 23 and 24: EfficACy and SafeTy of Ezetimibe Ad
Page 25 and 26: EfficACy and SafeTy of Ezetimibe Ad
Page 27 and 28: The Vytorin on CIMT and Overall Art
Page 29 and 30: A Recent Meta-analysis May 2011 27
Page 31 and 32: LDL-C Goal Achievement 100 90 80 70
Page 33 and 34: SHARP: Rationale • Risk of vascul
Page 35 and 36: Study of Heart And Renal Protection
Page 37 and 38: Proportion suffering event (%) SHAR
Page 39 and 40: Proportion suffering event (%) SHAR
Page 41 and 42: First ESC/EAS guidelines for dyslip
Page 43: Overall Conclusion • A beneficial

Statin/Ezetimbe Combination Therapy: Emerging Evidence

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