Statin/Ezetimbe Combination Therapy: Emerging Evidence
Statin/Ezetimbe Combination Therapy: Emerging Evidence
Statin/Ezetimbe Combination Therapy: Emerging Evidence
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INHIBITION OF CHOLESTEROL SYNTHESIS RESULTS IN A HIGHER<br />
ABSORPTION RATE OF CHOLESTEROL FROM THE INTESTINE*<br />
HEPATIC<br />
BIOSYNTHESIS<br />
INTESTINAL<br />
ABSORPTION<br />
Inhibition of<br />
cholesterol synthesis<br />
(simvastatin 10-80 mg)<br />
Food<br />
STATINS<br />
30-50% absorption<br />
synthesis<br />
absorption<br />
Cholesterol<br />
excreted in the<br />
faeces<br />
LDL-C<br />
31-46%<br />
* Measured as the ratio of serum levels of cholesterol absorption marker (sitosterol) and total cholesterol.<br />
Assmann G, et al. J Am Coll Cardiol 2004;43(5, Suppl. 2):A445-A446; Goldberg AC, et al. Mayo Clin Proc. 2004 May;79(5):620-9.
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