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Abstracts 589
FP-M-019
The clinical significance of evaluation of glucose
metabolism of brain with FDG-PET brain image during
the phase and interphase of refractory epilepsy in
children
Q.-X. Zhai, X.-Y. Lin, X.-H. Zhou, Z.-X. Qiao, Y.-X.
Zhang, H.-X. Qiao
Department of Pediatrics, Guangdong Provincial People’s
Hospital, Guangzhou, China
Objective: To assess the diagnostic value of 18F-FDG
imaging for interictal and ictal epileptic foci. Methods:
Twenty-three patients with refractory epilepsy were examined
in the interictal and ictal periods by 18F-FDG PET, the
results of examination have been compared with MRI and
EEG. The patients are ten cases in male, 13 cases in female.
The youngest is a 1 year old, the oldest is 14 years old.
Result: There are some abnormal metabolism focuses on
PET imaging in 21 (91.3%) patients with epilepsy. Lower
metabolism focus is in 19 cases, higher metabolism focus is
in two cases; and two cases is in normal. One case of two
with higher metabolism focus had seizures during the examination.
Before examination in 3 h there is an epileptic
attack in other one case. The epileptic focus had been
moved by operation in another two cases. It has been
found that the location of focus is the same with the abnormal
metabolism focus from PET. Younger children with
epilepsy, their abnormal metabolism focus is much more
than elder children. MRI is abnormal in 69%, EEG is abnormal
in 86%. Conclusions: The diagnostic value of 18F-FDG
PET imaging foci was higher than that of MRI and EEG in
sensitivity. The specificity and accuracy of 18F-FDG PET
imaging for the diagnosis of epilepsy during epilepsy ictal
period will be the best.
FP-M-020
Diagnostic value of MRA on acute hemiplegia syndrome
in childhood
W.-C. Zhang, H.-H. Wu, T.-C. Liou
Department of Neurology, Beijing Children Hospital, Beijing,
China
Objective: To study the diagnostic value of MRA on
acute hemiplegia syndrome. Methods: Thirty-four AHS
children were studied by 3D TOF MRA, using MRI as the
combined diagnostic method. Results: Twenty-four patients
had cerebrovascular abnormalities including nine stenoses
and 15 severe narrowing or occlusions, which were respectively
located in ICA of 11 patients, MCA of 24 patients,
and ACA of six patients. MRA showed vascular compensation
of 20 patients. Conclusion: The results indicate that
MRA showed good ability of deterting intracranial vascular
disorders in AHS study as a non-invasive, quick and efficient
tool with no need of radiographic agent. MRA will
probably become an important and commonly used diagnostic
technique for CVD in children.
FP-M-021
Functional MRI study in school children with attention
deficit hyperactivity disorder
Z. Jin a , L. Zhang a , Y.-F. Zang b , Y.-W. Zeng a , Y. Wang a , Y.-
F. Wang b
a fMRI Center, Hospital 306, Beijing, China; b Mental Institute,
Peking University, Beijing, China
Background: ADHD is a major developmental disorder
affecting 3–7% of school children, which is associated with
a low educational outcome and increased risk for antisocial
disorders and/or drug abuse in adulthood. The pathogenic
mechanisms of ADHD remain unknown. Method: Brain
activation maps had been observed pre and post one dose
of Ritalin (10 mg) in nine schoolboys with ADHD (aged 10–
14 years) and nine matched healthy controls using blood
oxygenation level dependent (BOLD) functional MRI technique.
Event-related Simon tasks contained neutral and
interference tasks were served as the stimuli. Results:
Comparing with healthy controls, ADHD children showed
significantly reduced activity in the prefrontal lobe, anterior
cingulate cortex, basal ganglia, cerebellum, and inferior
parietal lobulus during interference (difficult) task. During
neutral (easy) task, reduced activities in ADHD children
were mainly found in the prefrontal lobe, whereas more
activation was found in basal ganglia, cerebellum, and inferior
parietal lobules in patients compared with those in
healthy controls. After one dose of Retalin, reduced brain
activation were recovered in ADHD group. Conclusion: In
ADHD children, there seems to be some dysfunctional brain
areas, including prefrontal lobe, basal ganglia, cerebellum,
and inferior parietal lobulus. Retalin may help to reverse the
dysfunction partially.
FP-M-022
Early detection of hypoxic injury of the fetal human
brain by using MRI and 1 H MRS
V.A. Rogozhyn a , Z.Z. Rozhkova a , L.G. Kirillova b , E.M.
Lukjanova b , A.P. Perfilov b
a Radiological Center, Academy of Medical Sciences of
Ukraine, Kyiv, Ukraine; b Institute for Pediatrics, Obstetrics
and Gynecology, Academy of Medical Sciences of Ukraine,
Kyiv, Ukraine
Our goal is evaluating the brain anomalies in human
fetus by MRI, for measurement of fetal brain structures,
and 1 H MRS, for determination of cerebral metabolite
concentrations. Two groups of 17 women with (G1) and
15 women without (G2) complicated pregnancies are
studied by 1.5 T Magnetom Vision System (SIEMENS).
MR-images of fetal brain in utero (from 25 to 39 weeks of