Calcium Phosphate Excipients - Innophos

Table 8
Properties Of Aged DI-TAB ® Tablets
Aging Conditions Hardness Weight Thickness Disintegration
(kp) (mg) (mm) (min.)
Initial 19 751 4.94 0.3
1 Month R.T., Closed 19 751 4.91 0.3
1 Month 50˚, Closed 18 661* 4.92 1.2
1 Month, R.T., 75% R.H. 17 752 4.92 0.6
Tablets made at 30kN applied force; 7/16-in. standard cup tooling.
*Weight loss is due to loss of DI-TAB ® water of hydration at high temperature.
Direct Compression Tableting with TRI-TAB ®
A typical compressibility profile for TRI-TAB ® is shown in Figure 15. Data is listed in Table 9. The addition of
microcrystalline cellulose (AVICEL ® PH-101) increases tablet hardness and extends the capping point to
higher compression forces, as shown in Figure 16.
Figure 15 Figure 16
Tablet Hardness (kp)
20
16
12
8
4
0
8
TRI-TAB ®
10 12 14 16 18 20 22
Compaction Force (kN)
Tablet Hardness (kp)
20
16
12
8
4
TRI-TAB ® +
20% AVICEL ® TRI-TAB ® +
10% AVICEL ®
TRI-TAB ®
0
8 12 16 20 24 28 32
Compaction Force (kN)
COMPRESSIBILITY PROFILE FOR TRI-TAB ® COMPRESSIBILITY PROFILE FOR TRI-TAB ® containing 10 and 20%
AVICEL ® PH-101 microcrystalline cellulose.
Table 9
TRI-TAB ® Tablet Properties
Force Hardness Weight Disintegration (minutes)
(kp) (mg)(%RSD) (mm) Initial 1 Month 2 Months
15.3 7.6 731.6 (0.41) 0.3 0.4 0.4
20.1 9.8 734.2 (0.30) 0.7 0.5 0.4
14.9 7.0 752.5 (0.18) 0.4 0.4 0.4
20.9 9.3 755.3 (0.23) 1.1 0.8 0.5
13.4 6.6 748.9 (0.40) 0.4 0.6 –
17.7 9.0 754.0 (0.33) 0.8 0.9 –
16