Calcium Phosphate Excipients - Innophos

Relative A.N.C. (%)
Figure 18
Antacid Properties of Calcium Phosphates
100
90
80
70
60
50
40
30
20
10
0
37
DI-TAB ®
Disintegration
43
A-TAB ®
Acid Neutralization Capacity Relative to CaCO 3 .
Antacid Properties of
Calcium Phosphates
TRI-TAB ® TCP-DC
The calcium phosphates, when tableted, do not
disintegrate readily. They are quite water insoluble
69
73
100
CaCO3
Often overlooked are the significant antacid
properties accessible from formulating with the
calcium phosphates. As the graph demonstrates
(Figure 18), the tricalcium phosphates have
approximately 70% the acid neutralization capacity
of CaCO 3
. TCP-DC in a chewable tablet can offer
the same antacid properties as leading brands in
a gentle, non-bloating formula with the additional
benefit of phosphorus to better support bone health.
Tapped Volume (cc/g)
2.0
1.0
Figure 19
10 20 30 40
Number of Taps
Consolidation Volume (cc/g) as a function of number of taps.
A-TAB ®
DI-TAB ®
TRI-TAB ®
Excipient CV (%RSD) Flow (g/sec)
A-TAB ® 0.4 28
DI-TAB ® 0.2 33
TRI-TAB ® 0.3 39
and dissolve in dilute hydrochloric acid by erosion.
All of the calcium phosphate tablets do disintegrate
rapidly with the use of appropriate disintegrants.
Both the traditional starch and the newer
superdisintegrants, such as croscarmellose sodium,
crospovidone and sodium starch glycolate, can
be formulated with calcium phosphates. The
appropriate use level is, of course, dependent
on the formulated blend. Because the calcium
phosphate tablets contain void volume (in which
the disintegrant can reside), the wetting and
swelling pressure generated by the disintegrant
is especially effective.
Consolidation
Rapid consolidation of an excipient in a rotary
press die is an advantage, especially in high-speed
rotary presses which allow minimal time for die fill,
formulation consolidation and tablet compression.
The excellent consolidation properties of the
granular calcium phosphates are illustrated in
Figure 19, which describes consolidated bed
volume as a function of tapping.
Flow
Table 11
Coefficient of Variation of Tablet Weights of A-TAB ® , DI-TAB ® and TRI-TAB ®
indicating excellent flow properties.
DI-TAB ® , A-TAB ® , and TRI-TAB ® exhibit excellent
flow rates. The flowing excipients exhibit no
bridging or ratholing in a hopper. Good flow is also
demonstrated by the low coefficient of variation of
tablet weight (% relative standard deviation) typical
of tablets, These flow properties are illustrated in
Table 11.
18