Calcium Phosphate Excipients - Innophos
Calcium Phosphate Excipients - Innophos
Calcium Phosphate Excipients - Innophos
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TABLE OF CONTENTS<br />
Page Number<br />
Clinical trials<br />
demonstrate the<br />
positive effect<br />
of calcium and<br />
phosphorus<br />
supplimentation<br />
in osteoporosis<br />
sufferers who<br />
receive bone<br />
building therapy.<br />
SECTION 1: THE LEADER IN CALCIUM PHOSPHATES<br />
The Leader in <strong>Calcium</strong> <strong>Phosphate</strong> <strong>Excipients</strong> ...............1<br />
An Introduction to <strong>Calcium</strong> <strong>Phosphate</strong>s .........................1<br />
Manufacture of <strong>Calcium</strong> <strong>Phosphate</strong>s ...............................2<br />
SECTION 2: METHODS FOR THE PREPARATION OF TABLETS<br />
Methods for the Preparation of Tablets...........................3<br />
SECTION 3: PHYSICAL AND CHEMICAL PROPERTIES<br />
Physical and Chemical Properties.....................................5<br />
Formulas and Nomenclature ..............................................5<br />
<strong>Calcium</strong> and Phosphorus Content....................................6<br />
Scanning Electron Photomicrographs..............................7<br />
Particle Size Distributions.....................................................9<br />
Adsorption Isotherm..............................................................9<br />
Moisture ..................................................................................10<br />
Compatibilities and Stability .............................................10<br />
Thermal Behavior .................................................................11<br />
Solubility..................................................................................11<br />
Density .....................................................................................12<br />
SECTION 4: TABLETING PROPERTIES<br />
<strong>Calcium</strong> <strong>Phosphate</strong>s in Direct Compression ...............13<br />
Direct Compression with A-TAB ® .....................................13<br />
Direct Compression with DI-TAB ® ...................................15<br />
Direct Compression with TRI-TAB ® .................................16<br />
Direct Compression Tableting with TCP-DC ...............17<br />
Disintegration of <strong>Calcium</strong> <strong>Phosphate</strong> Tablets .............18<br />
Consolidation of <strong>Calcium</strong> <strong>Phosphate</strong>s ..........................18<br />
Flow of <strong>Calcium</strong> <strong>Phosphate</strong>s............................................18<br />
Lubrication of Tablets with <strong>Calcium</strong> <strong>Phosphate</strong><br />
Formulations ..........................................................................19<br />
Tooling <strong>Phosphate</strong> Formulations.....................................20<br />
Loading Capacity of <strong>Calcium</strong> <strong>Phosphate</strong>s ....................20<br />
SECTION 5: COMPLETE SERVICE SUPPORT<br />
Complete Service Support.................................................21<br />
Units of measurement, definition of terms .................23<br />
Bibliography ...........................................................................24
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