Cornea - I Free Papers - aioseducation

Cornea Free Papers
neovascularization, in experimental herpes simplex keratitis, and in studies
from human corneal buttons.
Also, VEGF inhibition has been shown to reduce corneal neovascularization
and improve corneal graft survival inexperimental animals.
In our study, we assessed the change in the area of pathologic vessels within
the cornea, whereas our grading system evaluated which of the 3 components
(extent, centricity, and density) responded most to the bevacizumab injection.
Indeed, a significant change in extent and density was shown, whereas
centricity of vessels did not react to the subconjunctival injection. Possibly, the
perilimbal application of the drug did not reach the more central part of the
vessel in the deep cornea. It is possible that these central vessels would respond
to a stromal injection rather than a perilimbal subconjunctival injection.
In conclusion, subconjunctival bevacizumab injection is efficacious in limiting
corneal neovascularization in human subjects. Whether this partial regression
of blood vessels is of clinical value needs to be studied in a randomized clinical
trial with a larger sample size and longer follow-up. Bevacizumab may also be
used in the future, as an adjunct to other drugs, for the treatment of corneal
neovascularization.
Neonatal Infectious Keratitis Five Years
Experience at a Tertiary Eye Care Center
Dr. Jatin Ashar, Dr. Muralidyhar R, Dr. Shivani Pahuja, Dr. Sunita
Chaurasia, Dr. Virender Sangwan
Neonatal keratitis is a serious, vision- threatening disease. Infections in this
age group are difficult to diagnose, manage and are uniquely at a grave
risk for secondary amblyopia. Several large studies on microbial keratitis have
been reported in children 1,2 however, literature on neonatal infectious keratitis
is limited.
To study the epidemiology, predisposing factors, clinico-microbial profile and
outcomes of neonatal microbial keratitis.
Study design: Retrospective, non consecutive, interventional case series.
MATERIALS AND METHODS
Medical records of 34 neonates (42 eyes) were analyzed for the age at
presentation, predisposing factors, systemic illness, clinical presentation,
microbiological profile, clinical course and outcomes. Examination was
performed using operating/ portable slit lamp microscope with /without
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