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Cornea Free Papers Table 1: Endothelial cell counts done by automated and manual methods in images from Fuchs’ dystrophy Number of Average Average Average Range of cells p value Images auto count manual count difference (difference) Cell count 49 2028.73 ± 329.53 1719.82±489.47 312.96±337.27 402 to 2 cells
69th AIOC Proceedings, Ahmedabad 2011 in compromised endothelium as automated count overestimates the results, and can even give a value in normal range, thus misleading the clinician. REFERENCES 2. Klais CM, Bühren J, Kohnen T. Comparison of endothelial cell count using confocal and contact specular microscopy. Ophthalmologica. 2003;217:99-103. 3. Módis L Jr, Langenbucher A, Seitz B. Corneal endothelial cell density and pachymetry measured by contact and noncontact specular microscopy. J Cataract Refract Surg. 2002;28:1763-9. 4. Doughty MJ. Toward a quantitative analysis of corneal endothelial cell morphology: a review of techniques and their application. Optom Vis Sci. 1989;66:626-42. 5. NAVIS for Confoscan 4 Operator’s Manual ©2005-2007. 6. Imre L, Nagymihály A. Reliability and reproducibility of corneal endothelial image analysis by in vivo confocal microscopy. Graefes Arch Clin Exp Ophthalmol. 2001;239:356-60. Streptococcus Pneumoniae Keratitis: Fortified Antibiotics or Fluoroquinolones? Dr. Sujata Das, Dr. Savitri Sharma, Dr. Vivek Warkad, Dr. Srikant K Sahu Fortified topical ocular antimicrobial (usually cephalosporin and aminoglycoside) is frequently administered to cover the maximum spectrum of bacteria in cases of severe bacterial keratitis. Treatment is modified according to the clinical response and sensitivity of the microorganism. 1-4 Frequent dosing of multiple antibiotics may result in increased toxicity and damage to the ocular surface epithelium. 2,3 For antimicrobial therapy to be effective in cases of microbial keratitis, it should reach the site of corneal infection in sufficient concentration to inhibit and preferably kill the causative microorganism while causing minimal or no toxicity to the host. Several factors modulate the interaction between drug, microorganisms, and the host. The purpose of this study was to test in vitro susceptibility of Streptococcus pneumoniae isolated from patients with microbial keratitis in order to determine the most suitable antibiotic for the treatment of keratitis caused by the organism. MATERIALS AND METHODS The medical and laboratory records of all culture-proven cases of S pneumoniae keratitis diagnosed at the L V Prasad Eye Institute, Bhubaneswar, India between November 2006 and December 2009 were reviewed retrospectively. All patients had undergone detailed clinical evaluation and 508
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Page 22 and 23: Cornea Free Papers Corneal scraping
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Page 30 and 31: Cornea Free Papers RESULTS Average
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