2010 Annual Report - Institute for Molecular Bioscience - University ...

105 publications
Publications 2010
MOLECULAR GENETICS AND
DEVELOPMENT (CONTINUED)
Beverdam, A., Svingen, T., Bagheri-Fam,
S., McClive, P., Sinclair, A.H., Harley, V.R.,
and Koopman, P. (2010). Protein tyrosine
kinase 2 beta (PTK2B), but not focal
adhesion kinase (FAK), is expressed in a
sexually dimorphic pattern in developing
mouse gonads. Developmental Dynamics
239: 2735-2741.
Bowles, J., Feng, C.-W., Spiller, C.,
Davidson, T.-L., Jackson, A., and
Koopman, P. (2010). FGF9 suppresses
meiosis and promotes male germ cell fate
in mice. Developmental Cell 19: 440-449.
Bowles, J., and Koopman, P. (2010).
Sex determination in mammalian germ
cells: extrinsic versus intrinsic factors.
Reproduction 139: 943-958.
Bruce, S.J., Butterfield, N.C., Metzis, V.,
Town, L., McGlinn, E., and Wicking, C.
(2010). Inactivation of Patched1 in the
mouse limb has novel inhibitory effects
on the chondrogenic program. Journal of
Biological Chemistry 285: 27967-27981.
Butterfield, N.C., McGlinn, E., and Wicking,
C. (2010). Chapter nine: The molecular
regulation of vertebrate limb patterning.
Current Topics in Developmental Biology
90: 319-341.
Chiu, H.S., Szucsik, J.C., Georgas, K.M.,
Jones, J.L., Rumballe, B.A., Tang, D.,
Grimmond, S.M., Lewis, A.G., Aronow,
B.J., Lessard, J.L., and Little, M.H. (2010).
Comparative gene expression analysis
of genital tubercle development reveals a
putative appendicular Wnt7 network for the
epidermal differentiation. Developmental
Biology 344: 1071-1087.
Christ, A.N., Labzin, L., Bourne, G.T.,
Fukunishi, H., Weber, J.E., Sweet, M.J.,
Smythe, M.L., and Flanagan, J.U. (2010).
Development and characterization
of new inhibitors of the human and
mouse hematopoietic prostaglandin D-2
synthases. Journal of Medicinal Chemistry
53: 5536-5548.
Combes, A.N., Spiller, C.M., Harley, V.R.,
Sinclair, A.H., Dunwoodie, S.L., Wilhelm,
D., and Koopman, P. (2010). Gonadal
defects in Cited2 -mutant mice indicate
a role for SF1 in both testis and ovary
differentiation. International Journal of
Developmental Biology 54: 683-689.
Duffy, D.L., Iles, M.M., Glass, D., Zhu, G.,
Barrett, J.H., Hoiom, V., Zhao, Z.Z., Sturm,
R.A., Soranzo, N., Hammond, C., Kvaskoff,
M., Whiteman, D.C., Mangino, M.,
Hansson, J., Newton-Bishop, J.A., Bataille,
V., Hayward, N.K., Martin, N.G., Bishop,
D.T., Spector, T.D., and Montgomery, G.W.
(2010). IRF4 Variants Have Age-Specific
Effects on Nevus Count and Predispose
to Melanoma. American Journal of Human
Genetics 87: 6-16.
Duffy, D.L., Zhao, Z.Z., Sturm, R.A.,
Hayward, N.K., Martin, N.G., and
Montgomery, G.W. (2010). Multiple
pigmentation gene polymorphisms account
for a substantial proportion of risk of
cutaneous malignant melanoma. Journal of
Investigative Dermatology 130: 520-528.
Endo-Munoz, L., Cumming, A., Rickwood,
D., Wilson, D., Cueva, C., Ng, C.,
Strutton, G., Cassady, A.I., Evdokiou, A.,
Sommerville, S., Dickinson, I., Guminski,
A., and Saunders, N.A. (2010). Loss of
Osteoclasts Contributes to Development
of Osteosarcoma Pulmonary Metastases.
Cancer Research 70: 7063-7072.
Ewen, K., Jackson, A., Wilhelm, D., and
Koopman, P. (2010). A male-specific role
for p38 mitogen-activated protein kinase
in germ cell sex differentiation in mice.
Biology of Reproduction 83: 1005-1014.
Ewen, K., and Koopman, P. (2010). Mouse
germ cell development: From specification
to sex determination. Molecular and
Cellular Endocrinology 323: 76-93.
KYLIE GEORGAS: POP NEON KIDNEYS
This artwork is a pop art version of
a schematic diagram of embryonic
mouse kidneys. The diagram has
been modified from a kidney diagram
designed and drawn by Kylie Georgas
for the GUDMAP website and has
been enhanced and stylised for the
competition.
Georges, A., Ezaz, T., Quinn, A.E.,
and Sarre, S.D. (2010). Are reptiles
predisposed to temperature-dependent
sex determination Sexual Development
4: 7-15.
Harrison, M.J., Tang, Y.H., and
Dowhan, D.H. (2010). Protein arginine
methyltransferase 6 regulates multiple
aspects of gene expression. Nucleic Acids
Research 38: 2201-2216.
Johanson, H.C., Chen, W., Wicking,
C., and Sturm, R.A. (2010). Inheritance
of a novel mutated allele of the OCA2
gene associated with high incidence of
oculocutaneous albinism in a Polynesian
community. Journal of Human Genetics 55:
103-111.
Julian, E., Dave, R.K., Robson, J.P.,
Hallahan, A.R., and Wainwright, B.J.
(2010). Canonical Notch signaling is not
required for the growth of Hedgehog
pathway-induced medulloblastoma.
Oncogene 29: 3465-3476.
Julian, E., Hallahan, A.R., and
Wainwright, B.J. (2010). RBP-J is not
required for granule neuron progenitor
development and medulloblastoma
initiated by Hedgehog pathway activation
in the external germinal layer. Neural
Development 5: 27.
Kadekaro, A.L., Leachman, S., Kavanagh,
R.J., Swope, V., Cassidy, P., Supp, D.,
Sartor, M., Schwemberger, S., Babcock,
G., Wakamatsu, K., Ito, S., Koshoffer, A.,
Boissy, R.E., Manga, P., Sturm, R.A., and
Abdel-Malek, Z.A. (2010). Melanocortin
1 receptor genotype: an important
determinant of the damage response of
melanocytes to ultraviolet radiation. FASEB
Journal 24: 3850-3860.
Kashimada, K., and Koopman, P. (2010).
Sry: the master switch in mammalian sex
determination. Development 137: 3921-
3930.
Koopman, P. (2010). The delicate balance
between male and female sex determining
pathways: potential for disruption of early
steps in sexual development. In: Ewa
Rajpert-De Meyts, International Journal
of Andrology. Proceedings of the 5th
Copenhagen Workshop on Endocrine
Disrupters. 5th Copenhagen Workshop
on Endocrine Disrupters: Ubiquitous
Endocrine Disrupters and Possible Human
Health Effects, Copenhagen, Denmark,
(252-258). 20-22 May 2009