DC beads loaded with Irinotecan : precilinical and early clinical ...

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Beads Elasticity 20 Elastic modulus 20% compr (kPa) 15 10 5 0 DC Beads Irinotecan Doxorubicin Hepaspheres Compression of a microsphere monolayer to determine elastic modulus
Release measurement Flow Sotax CE 6 apparatus (37C) with n=6 implant cells, constant-flow CY7 pump (NaCL 0.9%, 5 ml/min) Spectrophotometric determination at 359 nm (irinotecan)
Page 1 and 2: DC beads loaded with Irinotecan : p
Page 3 and 4: Colorectal cancer chemotherapy % re
Page 5 and 6: Rationale for intra-arterial route
Page 7 and 8: Rationale for intra-arterial route
Page 9 and 10: Irinotecan loading DC beads - loade
Page 11: Hepasphere size 700 600 Mean diamet
Page 15 and 16: Irinotecan release DC Beads Drug lo
Page 17 and 18: Tumor necrosis -Diffuse liver metas
Page 19 and 20: In vivo Pharmakokinetic VX2 liver
Page 21 and 22: Peripheral sampling 4500 4000 Serum
Page 23 and 24: Tissue sampling 10000 9000 CPT11 in
Page 25 and 26: Tumor necrosis 1000 900 800 700 Ser

DC beads loaded with Irinotecan : precilinical and early clinical ...

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