DC beads loaded with Irinotecan : precilinical and early clinical ...

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Tumor necrosis -Diffuse liver metastasis obtained through intra-portal vein injection of CC531-lac-Z rat colorectal carcinoma cells In vitro 50% cell survival @ 50 μg at 48 h, 25 μg at 72 h No group with IA or IV Irinotecan : 48 hours : 72 hours Eyol E, Clin Exp Metastasi 2008.
In vivo Pharmakokinetic VX2 liver tumor • IV : 12 mg • IA : 12 mg • TACE : 6-16.5 mg (m=9.35) / 100-300 microns – Complete stasis PharmacoKinetic CPT11 & SN38* • Venous sampling (10min - 24H) • Tissue sampling (1, 6, 24H) – Tumor – Liver Quantification of tumor necrosis * SN38 is the most active metabolite of Irinotecan
Page 1 and 2: DC beads loaded with Irinotecan : p
Page 3 and 4: Colorectal cancer chemotherapy % re
Page 5 and 6: Rationale for intra-arterial route
Page 7 and 8: Rationale for intra-arterial route
Page 9 and 10: Irinotecan loading DC beads - loade
Page 11 and 12: Hepasphere size 700 600 Mean diamet
Page 13 and 14: Release measurement Flow Sotax CE
Page 15 and 16: Irinotecan release DC Beads Drug lo
Page 17: Tumor necrosis -Diffuse liver metas
Page 21 and 22: Peripheral sampling 4500 4000 Serum
Page 23 and 24: Tissue sampling 10000 9000 CPT11 in
Page 25 and 26: Tumor necrosis 1000 900 800 700 Ser

DC beads loaded with Irinotecan : precilinical and early clinical ...

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