DC beads loaded with Irinotecan : precilinical and early clinical ...
DC beads loaded with Irinotecan : precilinical and early clinical ...
DC beads loaded with Irinotecan : precilinical and early clinical ...
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Rationale for intra-arterial route<br />
101<br />
R art<br />
81<br />
61<br />
41<br />
21<br />
1 0.9<br />
0.5<br />
0.1<br />
E r<br />
R art =<br />
CL<br />
Q A (1 - E r )<br />
24 18 12 6<br />
Q A (L/h)<br />
- Rart : advantage of IA vs IV<br />
- Er :extraction ratio at 1st pass<br />
- QA : arterial flow - CL : Body clearance of the drug
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