DC beads loaded with Irinotecan : precilinical and early clinical ...

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Colorectal cancer chemotherapy % response rate FUDR FOLFIRI FOLFOX Iri. Oxal. 5 FU 10 % 5FU-FA FA 20 % 45 % LV5FU2 25 % 55 % 55 % 67 % 64 % Sytemic therapy Intra-arterial therapy • Improvement in response rate, namely due to Oxaliplatinum <strong>and</strong> <strong>Irinotecan</strong> • Intra-arterial delivery provide higher response rate for a given drug
Rationale for intra-arterial route Drug % Liver extraction Clearance TB (l/min) 5-FU 22-45 2-5 FUDR 69-92 5-15 IRINOTECAN 38-72 9-25 MITO-C 7-18 3-5 CDDP 8-50 0.3-0.5 DOXO 45-50 - R art = CL Q A (1 - E r ) - Rart : advantage of IA vs IV - Er :extraction ratio at 1st pass - QA : arterial flow - CL : Body clearance of the drug
Page 1 and 2: DC beads loaded with Irinotecan : p
Page 3: Colorectal cancer chemotherapy % re
Page 7 and 8: Rationale for intra-arterial route
Page 9 and 10: Irinotecan loading DC beads - loade
Page 11 and 12: Hepasphere size 700 600 Mean diamet
Page 13 and 14: Release measurement Flow Sotax CE
Page 15 and 16: Irinotecan release DC Beads Drug lo
Page 17 and 18: Tumor necrosis -Diffuse liver metas
Page 19 and 20: In vivo Pharmakokinetic VX2 liver
Page 21 and 22: Peripheral sampling 4500 4000 Serum
Page 23 and 24: Tissue sampling 10000 9000 CPT11 in
Page 25 and 26: Tumor necrosis 1000 900 800 700 Ser

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