DC beads loaded with Irinotecan : precilinical and early clinical ...
DC beads loaded with Irinotecan : precilinical and early clinical ...
DC beads loaded with Irinotecan : precilinical and early clinical ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Peripheral venous sampling<br />
4500<br />
40<br />
4000<br />
Serum CPT11<br />
35<br />
Serum SN38<br />
3500<br />
3000<br />
2500<br />
30<br />
25<br />
IV<br />
IA<br />
TACE<br />
2000<br />
20<br />
1500<br />
15<br />
1000<br />
IV<br />
10<br />
500<br />
IA<br />
TACE<br />
5<br />
0<br />
10 20 40 60 2H 4H 6H 12H 24H<br />
0<br />
10 20 40 60 2H 4H 6H 12H 24H<br />
• Reduced systemic peak levels by more than 50%<br />
Lower systemic toxicity expected for a given dose