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DC beads loaded with Irinotecan : precilinical and early clinical ...

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Peripheral venous sampling<br />

4500<br />

40<br />

4000<br />

Serum CPT11<br />

35<br />

Serum SN38<br />

3500<br />

3000<br />

2500<br />

30<br />

25<br />

IV<br />

IA<br />

TACE<br />

2000<br />

20<br />

1500<br />

15<br />

1000<br />

IV<br />

10<br />

500<br />

IA<br />

TACE<br />

5<br />

0<br />

10 20 40 60 2H 4H 6H 12H 24H<br />

0<br />

10 20 40 60 2H 4H 6H 12H 24H<br />

• Reduced systemic peak levels by more than 50%<br />

Lower systemic toxicity expected for a given dose

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