DC beads loaded with Irinotecan : precilinical and early clinical ...

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Tumor necrosis -Diffuse liver metastasis obtained through intra-portal vein injection of CC531-lac-Z rat colorectal carcinoma cells - Surgical access to GDA : occluded flow and blind delivery of embolics 7525 microns ‣Bland embolization ‣ DEBIRI 20mg/kg ‣ DEBIRI 30mg/kg Eyol E, Clin Exp Metastasi 2008.
Tumor necrosis -Diffuse liver metastasis obtained through intra-portal vein injection of CC531-lac-Z rat colorectal carcinoma cells 140 120 Tumour cell number Liver weight 100 % treatment/control 80 60 40 p=0.05 p=0.07 p=0.04 p=0.02 20 IRI-Beads animal Bland embol animal 0 20 mg/kg 30 mg/kg Control Irinotecan-Beads Bland Embo Significant reduction in tumour burden and liver weight of IRI-Beads vs bland embolization Eyol E, Clin Exp Metastasi 2008.
Page 1 and 2: DC beads loaded with Irinotecan : p
Page 3 and 4: Colorectal cancer chemotherapy % re
Page 5 and 6: Rationale for intra-arterial route
Page 7 and 8: Rationale for intra-arterial route
Page 9 and 10: Irinotecan loading DC beads - loade
Page 11 and 12: Hepasphere size 700 600 Mean diamet
Page 13 and 14: Release measurement Flow Sotax CE
Page 15: Irinotecan release DC Beads Drug lo
Page 19 and 20: In vivo Pharmakokinetic VX2 liver
Page 21 and 22: Peripheral sampling 4500 4000 Serum
Page 23 and 24: Tissue sampling 10000 9000 CPT11 in
Page 25 and 26: Tumor necrosis 1000 900 800 700 Ser

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