The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure
The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure
The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure
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Why <strong>NT</strong>-<strong>pro<strong>BNP</strong></strong><br />
I. <strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> is more stable than <strong>BNP</strong>*<br />
Mean recovery <strong>of</strong> <strong>BNP</strong> w<strong>as</strong> less than 70% after one day <strong>of</strong> storage at –20°C <strong>and</strong><br />
decre<strong>as</strong>ed to less than 50% after two to four months <strong>of</strong> storage<br />
II.<br />
III.<br />
IV.<br />
<strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> values are generally more precise**<br />
<strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> <strong>as</strong>says have shown excellent within run <strong>and</strong> total precision with total CV<br />
ranging from 2.9% to 6.1%. In contr<strong>as</strong>t, total CV for <strong>BNP</strong> ranged from 9.9% to 12.5%,<br />
which is approximately 2-3 fold higher than the <strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> method.<br />
<strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> is a better predictor <strong>of</strong> patient outcomes***<br />
<strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> w<strong>as</strong> superior to <strong>BNP</strong> for predicting mortality <strong>and</strong> morbidity (P=0.032) or<br />
hospitalization for HF (P=0.0143)<br />
<strong>NT</strong>-<strong>pro<strong>BNP</strong></strong> <strong>as</strong>says are harmonized****<br />
Common source <strong>of</strong> antibodies (Roche)<br />
Age-related cut <strong>of</strong>f values established<br />
Sources: * Mueller et al, Clin Chem Lab Med (2004) 42:942-944.<br />
** Yeo et al, Clin Chim Acta (2003) 338:107-15.<br />
*** M<strong>as</strong>son et al, Clin Chem (2006) 52:1528-38 .<br />
**** Januzzi et al, Am J Cardiol (2008) 101: 9A-15A.<br />
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