The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure
The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure
The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure
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<strong>Use</strong> <strong>of</strong> <strong>BNP</strong> Assay<br />
• “…useful in establishing or excluding the diagnosis <strong>of</strong><br />
CHF in patients with acute dyspnea.”<br />
• 100 pg/ml cut<strong>of</strong>f (for ruling out)<br />
• 90 % sensitivity<br />
• 76% specificity<br />
• 89% NPV<br />
• <strong>BNP</strong> > 500 pg/ml PPV=90%<br />
• Grey zone 100pg/ml-500pg/ml where there are a<br />
number <strong>of</strong> conditions that could cause incre<strong>as</strong>ed levels<br />
Source: Maisel et al, New Eng J Med (2002) 347:161-167.<br />
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