The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure

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Use of BNP Assay • “…useful in establishing or excluding the diagnosis of CHF in patients with acute dyspnea.” • 100 pg/ml cutoff (for ruling out) • 90 % sensitivity • 76% specificity • 89% NPV • BNP > 500 pg/ml PPV=90% • Grey zone 100pg/ml-500pg/ml where there are a number of conditions that could cause increased levels Source: Maisel et al, New Eng J Med (2002) 347:161-167. 4
“Breathing Not Properly” Multinational Study Source: Maisel et al, New Eng J Med (2002) 347:161-167. 5
Page 1 and 2: The Use of NT-proBNP and BNP as Bio
Page 3: B-type Natriuretic Peptides Pre-Pro
Page 7 and 8: ValHeft Study: 2006 LVEF: left vent
Page 9 and 10: NT-proBNP Levels by Diagnosis in Pa
Page 11 and 12: VITROS ® NT-proBNP - Method Compar
Page 13 and 14: NT-proBNP in the Acute Setting 13
Page 15 and 16: NT-proBNP Levels by Diagnosis in Pa
Page 17 and 18: NT-proBNP Levels Predict Survival i
Page 19 and 20: Age-independent Rule-out Cut-point
Page 21 and 22: NT-proBNP vs BNP for Acute Heart Fa
Page 23 and 24: VITROS ® NT-proBNP - Intended Use
Page 25 and 26: NT-proBNP-Tailored CHF Therapy The
Page 27 and 28: Study Endpoints •1 endpoint •To
Page 29 and 30: Primary Endpoint 100 events P =.009
Page 31 and 32: Events as a function of NT-proBNP P
Page 33: QUESTIONS 33

The Use of NT-proBNP and BNP as Biomarkers of Acute Heart Failure

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