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Confounding, interaction, and mediation in multivariable/multivariate ...

Confounding, interaction, and mediation in multivariable/multivariate ...

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Mediation<br />

<strong>Confound<strong>in</strong>g</strong><br />

Interaction<br />

3 examples<br />

Def<strong>in</strong>ition <strong>and</strong> identification<br />

An application<br />

Approach 1: results<br />

Model<br />

Coefficient<br />

SE<br />

F<br />

p<br />

ols (Ki67~ EGFR+)<br />

: 0.0003069<br />

0.0001400<br />

4.80<br />

0.0340<br />

ols (AKT~ EGFR+)<br />

: 0.6584<br />

0.1996<br />

10.89<br />

0.0020<br />

ols (Ki67~ EGFR+AKT+)<br />

: 0.0003019<br />

0.0000993<br />

9.24<br />

0.0042<br />

ols (Ki67~ EGFR+AKT+)<br />

’: 0.00009687<br />

0.0001444<br />

0.45<br />

0.5061<br />

logo<br />

William Wu<br />

Cancer Biostatistics

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