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Confounding, interaction, and mediation in multivariable/multivariate ...

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Mediation<br />

<strong>Confound<strong>in</strong>g</strong><br />

Interaction<br />

Def<strong>in</strong>ition <strong>and</strong> determ<strong>in</strong>ation<br />

Methods for confound<strong>in</strong>g effect<br />

Unobserved confound<strong>in</strong>g<br />

Difference from <strong>mediation</strong><br />

What is a confounder<br />

Criteria for a confounder<br />

1 It is a risk factor for the disease, <strong>in</strong>dependent of the putative<br />

risk factor (exposure variable or X).<br />

2 It is associated with putative risk factor (exposure).<br />

3 It is not <strong>in</strong> the causal pathway between exposure <strong>and</strong> disease.<br />

logo<br />

William Wu<br />

Cancer Biostatistics

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