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Confounding, interaction, and mediation in multivariable/multivariate ...

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Mediation<br />

<strong>Confound<strong>in</strong>g</strong><br />

Interaction<br />

Def<strong>in</strong>ition<br />

Determ<strong>in</strong>ation of <strong><strong>in</strong>teraction</strong><br />

Difference from <strong>mediation</strong> <strong>and</strong> confound<strong>in</strong>g<br />

A note<br />

The statistical power to test the significant <strong><strong>in</strong>teraction</strong> is 5-times<br />

lower that to test ma<strong>in</strong> effect. So, p = 0.10 could be considered<br />

significant. Keep <strong>in</strong> m<strong>in</strong>d we do not want to miss any important<br />

<strong><strong>in</strong>teraction</strong>.<br />

logo<br />

William Wu<br />

Cancer Biostatistics

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