Confounding, interaction, and mediation in multivariable/multivariate ...
Confounding, interaction, and mediation in multivariable/multivariate ...
Confounding, interaction, and mediation in multivariable/multivariate ...
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Mediation<br />
<strong>Confound<strong>in</strong>g</strong><br />
Interaction<br />
3 examples<br />
Def<strong>in</strong>ition <strong>and</strong> identification<br />
An application<br />
P<strong>in</strong>gsheng’s study<br />
Study question:<br />
Whether <strong>and</strong> how childhood asthma was associated with maternal smok<strong>in</strong>g <strong>and</strong><br />
<strong>in</strong>fancy bronchiolitis.<br />
Prelim<strong>in</strong>ary model<strong>in</strong>g f<strong>in</strong>d<strong>in</strong>g:<br />
The significant association between maternal smok<strong>in</strong>g <strong>and</strong> asthma was found, but the<br />
association was gone after adjust<strong>in</strong>g for bronchiolitis <strong>in</strong> <strong>multivariable</strong> model<strong>in</strong>g.<br />
”We hypothesize that one mechanism through which maternal smok<strong>in</strong>g dur<strong>in</strong>g<br />
pregnancy contributes to the known <strong>in</strong>creased risk of develop<strong>in</strong>g childhood asthma is<br />
through <strong>in</strong>creas<strong>in</strong>g the risk of an important <strong>in</strong>termediate event, bronchiolitis dur<strong>in</strong>g<br />
<strong>in</strong>fancy.”<br />
logo<br />
William Wu<br />
Cancer Biostatistics
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