Confounding, interaction, and mediation in multivariable/multivariate ...
Confounding, interaction, and mediation in multivariable/multivariate ...
Confounding, interaction, and mediation in multivariable/multivariate ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Mediation<br />
<strong>Confound<strong>in</strong>g</strong><br />
Interaction<br />
Def<strong>in</strong>ition <strong>and</strong> determ<strong>in</strong>ation<br />
Methods for confound<strong>in</strong>g effect<br />
Unobserved confound<strong>in</strong>g<br />
Difference from <strong>mediation</strong><br />
Consequence of confound<strong>in</strong>g<br />
ˆ Bias effect estimate.<br />
ˆ Widen confidence <strong>in</strong>terval.<br />
ˆ Inclusion of additional potential confounders may only widen<br />
the CI <strong>and</strong> have no impact of effect estimate.<br />
ˆ <strong>Confound<strong>in</strong>g</strong> is the mask<strong>in</strong>g of the true effect of a risk factor<br />
on a disease or outcome by the presence of another variable.<br />
ˆ The presence of confound<strong>in</strong>g effect leads to a spurious<br />
association between exposure <strong>and</strong> outcome.<br />
logo<br />
William Wu<br />
Cancer Biostatistics
Change language