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FASTA FAmily Score Test for Association (aka MMSCORE) Based on the mixed model Y = µ + B g + G + e FASTA test for association: (a) Estimate polygenic model Y = µ + G + e (b) Compute FASTA test (c) Apply GC afterwards if λ > 1 [extended in recent ProbABEL paper] Computation time ~ O(N 2 ) QTL/MAS Workshop, May 2010, Poznan Yurii Aulchenko Chen & Abecasis, 2007; Aulchenko & Struchalin, 2010
GRAMMAS-GC GW Rapid Association using Mixed Model And Score test Based on the mixed model Y = µ + B g + G + e GRAMMAS test for association: (a) Estimate polygenic model Y = µ + G + e (b) Compute environmental residuals (c) Runs score test on residuals (d) Apply GC (λ expected to be < 1) => grammas-gc Computation time ~ O(N) QTL/MAS Workshop, May 2010, Poznan Yurii Aulchenko Aulchenko et al, 2007; Amin et al., 2007
Page 1 and 2: Methods for GWA analysis in samples
Page 3 and 4: Reasons for genetic association Wha
Page 5 and 6: Genetic origin is a major confounde
Page 7 and 8: Skin color scan GWAS of skin color
Page 9 and 10: Genome-Wide Association analysis
Page 11 and 12: Nuclear pedigree QTL/MAS Workshop,
Page 13 and 14: Analysis of large complex pedigrees
Page 15 and 16: Idea of the genomic control • Mod
Page 17: Few notes on GC When stratification
Page 21 and 22: Relationship between genomes The es
Page 23 and 24: Genomic Φ is better than pedigree
Page 25 and 26: Recent developments: even better GR
Page 27 and 28: Recent developments: binary traits

Correlation

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