Correlation

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Genomic vs. Pedigree kinship • 1,400 ERF people genotyped for 6K Illumina Array • Trait values simulated based on observed genotypes • Associated SNPs explained from 0.3 to 4% of variance h 2 =30% h 2 =50% h 2 =80% Genomic Φ Pedigree Φ GC QTL/MAS Workshop, May 2010, Poznan Yurii Aulchenko
Genomic Φ is better than pedigree Φ • Pedigree is not guaranteed to be correct – Missing links => increased type 1 error • Pedigree relationship coefficient is the expected proportion of genome shared – Genomic relationship may better estimate true sharing QTL/MAS Workshop, May 2010, Poznan Yurii Aulchenko
Page 1 and 2: Methods for GWA analysis in samples
Page 3 and 4: Reasons for genetic association Wha
Page 5 and 6: Genetic origin is a major confounde
Page 7 and 8: Skin color scan GWAS of skin color
Page 9 and 10: Genome-Wide Association analysis
Page 11 and 12: Nuclear pedigree QTL/MAS Workshop,
Page 13 and 14: Analysis of large complex pedigrees
Page 15 and 16: Idea of the genomic control • Mod
Page 17 and 18: Few notes on GC When stratification
Page 19 and 20: GRAMMAS-GC GW Rapid Association usi
Page 21: Relationship between genomes The es
Page 25 and 26: Recent developments: even better GR
Page 27 and 28: Recent developments: binary traits

Correlation

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