Protein A - esonn
Protein A - esonn
Protein A - esonn
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<strong>Protein</strong> interactions: Genome wide approaches<br />
• Domains:<br />
- approx 1’000 types of domains in genome<br />
÷ for about 750 types, 1 or more structures known<br />
- about 10’000 types of domain-domain interactions are predicted<br />
÷ 20% have been structurally characterized<br />
=> Use functional and structural information to predict<br />
- interactions between domains, and thus between proteins<br />
- identify interactions that<br />
÷ can happen simultaneously<br />
÷ are sterically overlapping, and thus excluding<br />
- estimate by modeling<br />
÷ affinities<br />
÷ rate constants<br />
20