slides in pdf format - Department of Statistics - Rice University

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Outline 1. Background ideas • Genetic diseases and population structure • Problems of current approaches, and • How some new ideas might help
Outline 1. Background ideas • Genetic diseases and population structure • Problems of current approaches, and • How some new ideas might help 2. Some tech details • Basics of relatedness and inbreeding coefficient • How to estimate relatedness using genetic marker data
Page 1: Using Population Structure to Map C
Page 5 and 6: Genetic diseases A genetic disease
Page 7 and 8: Genetic diseases A genetic disease
Page 9 and 10: Life of a disease gene - a hard one
Page 11 and 12: Life of a disease gene - a hard one
Page 13 and 14: Life of a disease gene - some good
Page 15 and 16: Life of a disease gene - some good
Page 17 and 18: What do all these tell us • Disea
Page 19 and 20: Basic gene mapping methods Genes th
Page 21 and 22: What trouble can population structu
Page 23 and 24: In the case of complex disease Popu
Page 25 and 26: Using Population Structure to Map C
Page 27 and 28: Our Approach (cont.) • Measure th
Page 29 and 30: Tech details: Inbreeding Coefficien
Page 31 and 32: Tech details: Inbreeding Coefficien
Page 33 and 34: Estimate Inbreeding Coef. from Pedi
Page 35 and 36: Family Level Relatedness: Dr. Quell
Page 37 and 38: Dr. Queller’s Method (Cont. 1)
Page 39 and 40: Dr. Queller’s Method (Cont. 1)
Page 41 and 42: Locus Level Relatedness Measures Th
Page 43 and 44: Locus Level Relatedness Measure (Co
Page 45 and 46: • What I have done Summary and Fu
Page 47: References [1] Balloux F. Easypop,

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