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Trident Nov 14 2005 - Tridentnews.ca

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28<br />

TRIDENT, NOVEMBER <strong>14</strong>, <strong>2005</strong><br />

Protein linked events leading to heart attack<br />

THE Ff FILES<br />

By CIHR<br />

DNews<br />

Ateam led by Dr. Janos Filep and<br />

funded by the Canadian Institutes<br />

of Health Research (CIHR),<br />

has uncovered a novel function for<br />

a protein known to elevate the risk<br />

of <strong>ca</strong>rdiac death. Their finding<br />

gives further insight into new<br />

avenues of treatment for combating<br />

heart attacks.<br />

The team’s research revolved<br />

around the role of the C-reactive<br />

protein and its link to acute coronary<br />

artery disease. The team<br />

expanded on recent research on C-<br />

reactive protein which showed that<br />

it acts as an indi<strong>ca</strong>tor of inflammation.<br />

The team found that a modified<br />

form of CRP <strong>ca</strong>lled mCRP stimulates<br />

the production of other proteins<br />

(cytokines) which control the<br />

level of leukocytes or white blood<br />

cells in circulation. In this instance,<br />

the presence of increased amount of<br />

white blood cells into the injured<br />

tissues <strong>ca</strong>uses inflammation around<br />

the coronary artery, and injury to<br />

the heart.<br />

“Our findings suggest that<br />

changes in the structure of the C-<br />

Research gives insight into treatment and prevention of heart attacks.<br />

reactive protein <strong>ca</strong>use the formation<br />

of other proteins that increase the<br />

presence of leukocytes in the<br />

injured tissues,” said Dr. Janos<br />

Filep, lead CIHR investigator, Faculty<br />

of Medicine, Université de<br />

Montréal. “This aggravates the<br />

injury, tightens circulation to the<br />

coronary artery and consequently<br />

<strong>ca</strong>uses inflammation and may provoke<br />

<strong>ca</strong>rdiac events.”<br />

This new understanding of the biologi<strong>ca</strong>l<br />

role of various forms of CRP<br />

may allow for treatments to be<br />

adjusted to reduce inflammation in<br />

the coronary arteries, thereby preventing<br />

the occurrence of acute coronary<br />

events and ultimately to reduce<br />

death from coronary artery disease.<br />

“The results of this research suggest<br />

that by targeting the C-reactive<br />

protein, we’ll have a better chance<br />

of one day countering coronary<br />

heart disease” said Dr. Bruce<br />

McManus, Scientific Director,<br />

CIHR’s Institute of Circulatory and<br />

Respiratory Health.<br />

Ph.D. students Tarek Khreiss and<br />

Levente Jozsef, recipients of CIHR<br />

Doctoral Research Awards, and Dr<br />

Lawrence A. Potempa of Immtech<br />

International where also part of the<br />

research team. These findings are<br />

published in the September 30,<br />

<strong>2005</strong> print and online edition of Circulation<br />

Research. This C-reactive<br />

protein study is part of a larger study<br />

funded by CIHR looking into the<br />

molecular mechanisms of how various<br />

forms of CRP regulate events<br />

underlying coronary artery disease.<br />

The Heart and Stroke Foundation<br />

of Quebec also contributed to<br />

this study.<br />

The Canadian Institutes of Health<br />

Research (CIHR) is the Government<br />

of Canada’s agency for health<br />

research. CIHR’s mission is to create<br />

new scientific knowledge and to <strong>ca</strong>talyze<br />

its translation into improved<br />

health, more effective health services<br />

and products, and a strengthened<br />

Canadian health <strong>ca</strong>re system. Composed<br />

of 13 Institutes, CIHR provides<br />

leadership and support to close<br />

to 10,000 health researchers and<br />

trainees across Canada.<br />

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