Trident Nov 14 2005 - Tridentnews.ca
Trident Nov 14 2005 - Tridentnews.ca
Trident Nov 14 2005 - Tridentnews.ca
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28<br />
TRIDENT, NOVEMBER <strong>14</strong>, <strong>2005</strong><br />
Protein linked events leading to heart attack<br />
THE Ff FILES<br />
By CIHR<br />
DNews<br />
Ateam led by Dr. Janos Filep and<br />
funded by the Canadian Institutes<br />
of Health Research (CIHR),<br />
has uncovered a novel function for<br />
a protein known to elevate the risk<br />
of <strong>ca</strong>rdiac death. Their finding<br />
gives further insight into new<br />
avenues of treatment for combating<br />
heart attacks.<br />
The team’s research revolved<br />
around the role of the C-reactive<br />
protein and its link to acute coronary<br />
artery disease. The team<br />
expanded on recent research on C-<br />
reactive protein which showed that<br />
it acts as an indi<strong>ca</strong>tor of inflammation.<br />
The team found that a modified<br />
form of CRP <strong>ca</strong>lled mCRP stimulates<br />
the production of other proteins<br />
(cytokines) which control the<br />
level of leukocytes or white blood<br />
cells in circulation. In this instance,<br />
the presence of increased amount of<br />
white blood cells into the injured<br />
tissues <strong>ca</strong>uses inflammation around<br />
the coronary artery, and injury to<br />
the heart.<br />
“Our findings suggest that<br />
changes in the structure of the C-<br />
Research gives insight into treatment and prevention of heart attacks.<br />
reactive protein <strong>ca</strong>use the formation<br />
of other proteins that increase the<br />
presence of leukocytes in the<br />
injured tissues,” said Dr. Janos<br />
Filep, lead CIHR investigator, Faculty<br />
of Medicine, Université de<br />
Montréal. “This aggravates the<br />
injury, tightens circulation to the<br />
coronary artery and consequently<br />
<strong>ca</strong>uses inflammation and may provoke<br />
<strong>ca</strong>rdiac events.”<br />
This new understanding of the biologi<strong>ca</strong>l<br />
role of various forms of CRP<br />
may allow for treatments to be<br />
adjusted to reduce inflammation in<br />
the coronary arteries, thereby preventing<br />
the occurrence of acute coronary<br />
events and ultimately to reduce<br />
death from coronary artery disease.<br />
“The results of this research suggest<br />
that by targeting the C-reactive<br />
protein, we’ll have a better chance<br />
of one day countering coronary<br />
heart disease” said Dr. Bruce<br />
McManus, Scientific Director,<br />
CIHR’s Institute of Circulatory and<br />
Respiratory Health.<br />
Ph.D. students Tarek Khreiss and<br />
Levente Jozsef, recipients of CIHR<br />
Doctoral Research Awards, and Dr<br />
Lawrence A. Potempa of Immtech<br />
International where also part of the<br />
research team. These findings are<br />
published in the September 30,<br />
<strong>2005</strong> print and online edition of Circulation<br />
Research. This C-reactive<br />
protein study is part of a larger study<br />
funded by CIHR looking into the<br />
molecular mechanisms of how various<br />
forms of CRP regulate events<br />
underlying coronary artery disease.<br />
The Heart and Stroke Foundation<br />
of Quebec also contributed to<br />
this study.<br />
The Canadian Institutes of Health<br />
Research (CIHR) is the Government<br />
of Canada’s agency for health<br />
research. CIHR’s mission is to create<br />
new scientific knowledge and to <strong>ca</strong>talyze<br />
its translation into improved<br />
health, more effective health services<br />
and products, and a strengthened<br />
Canadian health <strong>ca</strong>re system. Composed<br />
of 13 Institutes, CIHR provides<br />
leadership and support to close<br />
to 10,000 health researchers and<br />
trainees across Canada.<br />
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