Current issues in Hereditary Angioedema (HAE) - Ipopi

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• Cinryze (C1 ınhıbıtor) acute trials – 1000 units with second 1000 U dose after 1 hour – Not equivalent to 2000 units up front – Recommended dose 2000 units
Treatment of C1 inhibitor deficiency -Rhucin/Ruconest • Recombinant C1 inhibitor – Not blood product • Higher dose possible – 50U/ kg c.f. 20U/kg with Berinert • Purified from rabbit milk – Anaphylaxis in one severely rabbit allergic ‘normal’ volunteer – Otherwise v well tolerated – No significant antibody production • Short half life
Page 1 and 2: Current issues in Hereditary Angioe
Page 3 and 4: What is HAE (Hereditary • HAE 1 o
Page 5 and 6: C1 inhibitor controls inflammation
Page 7 and 8: What have we learnt about the new
Page 9: • Berinert (C1 inhibitor) trials
Page 13 and 14: Icatibant (Firazyr) • Recurrent a
Page 15 and 16: Living with hereditary angioedema:
Page 17 and 18: L’s story: 25 year old with HAE
Page 19 and 20: L’s story •15 th March 2010- 2
Page 21 and 22: Treatment of C1 inhibitor deficienc
Page 23 and 24: Self administration C1 ınhıbıtor
Page 25 and 26: C1 inhibitor controls local Healthy
Page 27: Rational use of steroids….
Page 30 and 31: Mr B 15 years • Unwilling to trai
Page 32 and 33: Mrs B 42 years • Danazol 100 mg a
Page 34 and 35: Need to control acute attacks
Page 36 and 37: What does everyone want • Patient
Page 38: Recent initiatives • World consen

Current issues in Hereditary Angioedema (HAE) - Ipopi

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