Current issues in Hereditary Angioedema (HAE) - Ipopi
Current issues in Hereditary Angioedema (HAE) - Ipopi
Current issues in Hereditary Angioedema (HAE) - Ipopi
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Treatment of C1 <strong>in</strong>hibitor deficiency<br />
-Rhuc<strong>in</strong>/Ruconest<br />
• Recomb<strong>in</strong>ant C1 <strong>in</strong>hibitor<br />
– Not blood product<br />
• Higher dose possible<br />
– 50U/ kg c.f. 20U/kg with Ber<strong>in</strong>ert<br />
• Purified from rabbit milk<br />
– Anaphylaxis <strong>in</strong> one severely rabbit allergic ‘normal’ volunteer<br />
– Otherwise v well tolerated<br />
– No significant antibody production<br />
• Short half life
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