Current issues in Hereditary Angioedema (HAE) - Ipopi

‘Acute dosing reactions’-ecallantide
(DX88; Kalbitor)
• 8 reports of anaphylactoid reactions (~514 treatments)
– May occur during first treatment
– Rhinitis, sneezing, itchy throat, laryngeal oedema, hypotension
– Some treated with adrenaline etc.
• Cause uncertain
– No relation of antibodies to risk of reactions
• 3 antiecallantide/7 anti-pichia (1 IgE)/1 antiecallantide & -pichia antibodies (8% of
180 patients tested)
– ‘Desensitisation’ in 6 of 8 patients-successful in 5
FDA recommends not to be used for self administration
Schneider JACI 2007; Zuraw Expert opinion invest
drugs 2008; Caballero, personal communication
2005