Golniški simpozij 2011 Zbornik povzetkov

Implications of sputum bacteriology
in acute exacerbations of chronic
obstructive pulmonary disease
Irena Øarc, Viktorija Tomiœ, Mitja Lainøœak,
Kristina Ziherl, Tina Jeriœ, Mitja Koønik, Stanislav Øuøkoviœ
University Clinic of Respiratory and Allergic Diseases, Golnik
Background
Pathogenic bacteria have been implicated as a causative agent in majority of episodes of acute exacerbation
of COPD (AECOPD). We aimed to investigate sputum bacteriology and prognostic implications
of sputum results in AECOPD.
Methods
We conducted a retrospective study of consecutive patients admitted to University Clinic Golnik with
AECOPD from 2002 to 2007. The diagnosis of COPD, sputum bacteriology and clinical characteristics
of patients were confirmed with detailed review of complete medical records. Only the initial hospitalization
of patients with quality sputum was included in the study. Vital status was obtained from
Central Population Registry.
Results
Final sample consisted of 697 patients (age 70 ±9 years, 75% men, 65% GOLD III/IV). Most frequently
isolated pathogens were H.influenzae (19.4%), P. aeroginosa (14.9%) and S. pneumoniae (11.8%). The
isolation of S. pneumoniae (p=0.009), P. aeroginosa (p=0.01), non-fermenting Gram negative bacilli
(p