Comparative Genomics-Basic and Applied Research.pdf

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A. (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) (19) (20) (21) (22) (23) (24) (25) Fluorescence Intensity G A T C G A C G A G T A G FIGURE 2.3 (See color figure in the insert following page 48.) Cyclic reversible termination: (A) 13-base CRT sequencing using the 3-O-allyl terminators developed by Ju and colleagues, 16 illustrating fluorescence scanned data and four-color intensity histogram plot. The template was immobilized to a solid support using the self-priming method (not shown). (B) Five panels illustrate Illumina’s single-molecule array (SMA) technology. 5 In panel 1, isolated genomic DNA is fragmented and ligated with adaptors, which are then made single-stranded and attached to the solid support. Bridge amplification (panel 2) is performed to create double-stranded templates (panel 3), which are denatured (panel 4) and bridge amplified several more times to create template clusters (panel 5). (C) Nine-base CRT sequencing highlighting two different template sequences. The series of images was obtained from a 40-million cluster SMA (not shown). (Panel A was reprinted from Ju et al., Proc. Natl. Acad. Sci. U. S. A. 103, 19635–19640, 2006, by permission of the National Academy of Sciences, U. S. A., copyright 2006. Figures 2.3B and 2.3C were obtained by permission from Illumina Inc.) Advances in Next-Generation DNA Sequencing Technologies 21
B. Adapter Add unlabeled nucleotides and enzyme to initiate solid-phase bridge amplification. DNA Fragment Adapter Dense lawn of primers Terminus Attached Terminus Free Attached Terminus Attached Attached C. T G C T A C G A T . . . 1 2 3 4 5 6 7 8 9 T T T T T T T G T . . . FIGURE 2.3 (Continued). Clusters 22 Comparative Genomics
Page 2 and 3: COMPARATIVE GENOMICS Basic and Appl
Page 4 and 5: Contents Preface ..................
Page 6: Chapter 18 Domestic Animals .......
Page 9 and 10: elationships among species is one o
Page 12: Editor Dr. James Brown iscurrentlya
Page 15 and 16: Steven M. Foord Molecular Discovery
Page 17 and 18: Emily Vucic British Columbia Cancer
Page 19 and 20: 2 Comparative Genomics The genome i
Page 21 and 22: 4 Comparative Genomics HGT is now r
Page 23 and 24: 6 Comparative Genomics to identify
Page 25 and 26: 8 Comparative Genomics 20. Smith, M
Page 28: Part I Basic Research in Comparativ
Page 31 and 32: 14 Comparative Genomics next-genera
Page 33 and 34: 16 Comparative Genomics A. B. E. (i
Page 35 and 36: 18 Comparative Genomics four colors
Page 37: 20 Comparative Genomics 2.4 CYCLIC
Page 41 and 42: 24 Comparative Genomics B. * 3 Natu
Page 43 and 44: 26 Comparative Genomics 17. Wu, W.
Page 45 and 46: 28 Comparative Genomics 64. Batters
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Page 49 and 50: 32 Comparative Genomics sequences,
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72 Comparative Genomics 47. Syed, A
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74 Comparative Genomics cake. This
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76 Comparative Genomics to begin wi
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78 Comparative Genomics became phag
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80 Comparative Genomics follows tha
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82 Comparative Genomics 5.8 CONCLUS
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84 Comparative Genomics 47. Ris, H.
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86 Comparative Genomics 94. Doolitt
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88 Comparative Genomics 6.1 INTRODU
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TABLE 6.1 Sequenced Genomes of Inve
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92 Comparative Genomics 6.2 CHARACT
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94 Comparative Genomics D. melanoga
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96 Comparative Genomics the sea urc
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98 Comparative Genomics genome info
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100 Comparative Genomics of the vol
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102 Comparative Genomics important
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104 Comparative Genomics 29. Dehal,
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106 Comparative Genomics 7.2 VERTEB
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108 Comparative Genomics 7.3 VERTEB
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TABLE 7.1 Vertebrate BAC Libraries
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112 Comparative Genomics TABLE 7.2
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114 Comparative Genomics in the mou
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116 Comparative Genomics organisms,
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118 Comparative Genomics and BAC li
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120 Comparative Genomics 42. Hirsch
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122 Comparative Genomics 87. Hedges
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124 Comparative Genomics 8.4.2.3 Us
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126 Comparative Genomics Thischapte
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128 Comparative Genomics versionsof
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132 Comparative Genomics famine,sev
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134 Comparative Genomics 8.4.2 APPR
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136 Comparative Genomics stability,
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138 Comparative Genomics core haplo
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140 Comparative Genomics whichinsom
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142 Comparative Genomics evidenceof
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146 Comparative Genomics Preliminar
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148 Comparative Genomics tests of s
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150 Comparative Genomics Instead,al
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152 Comparative Genomics 30. Tishko
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154 Comparative Genomics 77. Wang,
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9 Comparative Genomics in Drug Disc
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Comparative Genomics in Drug Discov
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p85i Ras BD C2 Helical Domain Catal
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178 Comparative Genomics 10.1 INTRO
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180 Comparative Genomics aim of pic
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182 Comparative Genomics access to
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184 Comparative Genomics this chapt
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186 Comparative Genomics during the
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188 Comparative Genomics 12. Hughes
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190 Comparative Genomics 57. Medini
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192 Comparative Genomics 98. Kwan,
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194 Comparative Genomics vaccine th
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196 Comparative Genomics mapping, a
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TABLE 11.1 Current Status of Parasi
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TABLE 11.1 Current Status of Parasi
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202 Comparative Genomics 11.3 THE C
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TABLE 11.2 Development Status of Va
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206 Comparative Genomics GAP (cytos
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208 Comparative Genomics experiment
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210 Comparative Genomics widely dif
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212 Comparative Genomics induced an
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214 Comparative Genomics foster col
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216 Comparative Genomics 49. Suroli
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218 Comparative Genomics 89. Bhatia
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220 Comparative Genomics on HIV com
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Lipid Bilayer SU TM A. B. HIV-1 PR
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224 Comparative Genomics assembled
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226 Comparative Genomics in hypermu
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228 Comparative Genomics roughly eq
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230 Comparative Genomics antibodies
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232 Comparative Genomics migration.
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234 Comparative Genomics This may e
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236 Comparative Genomics during tre
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238 Comparative Genomics PR33 L I F
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240 Comparative Genomics 18. Dalgle
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242 Comparative Genomics 64. Yusim,
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244 Comparative Genomics 107. Wensi
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246 Comparative Genomics A. Normal
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248 Comparative Genomics Database o
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250 Comparative Genomics alteration
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252 Comparative Genomics The applic
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254 Comparative Genomics A. Genomic
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256 Comparative Genomics 21. Wang,
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258 Comparative Genomics 66. Katoh,
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14 Comparative Cancer Epigenomics A
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Comparative Cancer Epigenomics 263
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Insulator Comparative Cancer Epigen
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282 Comparative Genomics Although t
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284 Comparative Genomics family rep
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286 Comparative Genomics Group 2 2
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288 Comparative Genomics in the Kre
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290 Comparative Genomics to Ensembl
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292 Comparative Genomics It is poss
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296 Comparative Genomics profiles w
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298 Comparative Genomics 30. Affyme
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300 Comparative Genomics including
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302 Comparative Genomics it is not
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304 Comparative Genomics high-to-lo
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306 Comparative Genomics assess sim
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308 Comparative Genomics array. Ana
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310 Comparative Genomics Genome Lev
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312 Comparative Genomics The RefSeq
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314 Comparative Genomics as GEO, NC
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316 Comparative Genomics putative t
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318 Comparative Genomics conserved
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320 Comparative Genomics 36. Curwen
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324 Comparative Genomics evolved fr
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326 Comparative Genomics 17.2.3 CER
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328 Comparative Genomics of the str
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330 Comparative Genomics 17.3.2 SIM
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332 Comparative Genomics basis for
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334 Comparative Genomics potential
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336 Comparative Genomics 31. Ma, L.
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338 Comparative Genomics 73. Salse,
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340 Comparative Genomics 116. Qi, L
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344 Comparative Genomics the causal
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346 Comparative Genomics a higher p
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348 Comparative Genomics feasible (
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350 Comparative Genomics 18.8.1 PLU
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352 Comparative Genomics Given the
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354 Comparative Genomics (allergens
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356 Comparative Genomics 2.0 1.8 1.
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358 Comparative Genomics has a majo
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360 Comparative Genomics 31. Brunbe
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362 Comparative Genomics 75. George
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364 Comparative Genomics APC, 253 A
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366 Comparative Genomics ChIP analy
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368 Comparative Genomics miRNA, 93
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370 Comparative Genomics Gene expre
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372 Comparative Genomics host inter
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374 Comparative Genomics Mammals co
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376 Comparative Genomics 3-OH group
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378 Comparative Genomics Protease i
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380 Comparative Genomics human geno
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382 Comparative Genomics V V224I, 3
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A. B. E. (iii) (ii) C. D. (i) COLOR
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C. T G C T A C G A T . . . 1 2 3 4
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-log(Q) 5.0 4.5 4.0 3.5 3.0 Selecti
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Cercopithecus aethiops GRI67AGM TAN
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