Large scale containment
Large scale containment
Large scale containment
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<strong>Large</strong> Scale<br />
• History (EU)<br />
• <strong>Large</strong> <strong>scale</strong> (>5 or 10 L) required an increase by one<br />
stage of the <strong>containment</strong> level<br />
e.g. B. pertussis (BL2) BL3 at large <strong>scale</strong><br />
• Appendix K (NIH): BLx BLx-<strong>Large</strong> Scale<br />
• BL1-<strong>Large</strong> Scale recommended for production of viable<br />
organisms containing rDNA that require BL1 at lab <strong>scale</strong><br />
• BL2-<strong>Large</strong> Scale recommended for production of viable<br />
organisms containing rDNA that require BL2 at lab <strong>scale</strong><br />
• BL3-<strong>Large</strong> Scale recommended for production of viable<br />
organisms containing rDNA that require BL3 at lab <strong>scale</strong><br />
• No provisions for production of viable organisms<br />
containing rDNA that require BL4 at lab <strong>scale</strong>
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